A5093849758- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Neurotransmitter Receptor Influence on Behavior
- Pancreatic function and diabetes
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
Centre Hospitalier de l’Université de Montréal
2024
Abstract α/β-hydrolase domain 6 (ABHD6) is a lipase linked to physiological functions affecting metabolism and body weight. Brain ABHD6 degrades 2-arachidonoylglycerol thereby modulates cannabinoid receptor signaling. However, it’s functional role within mesoaccumbens circuitry that critical for motivated behavior known be significantly modulated by endocannabinoids remained unknown. Using three viral approaches, we show control of the nucleus accumbens neuronal key determinant weight...
α/β-hydrolase domain 6 (ABHD6) is a lipase linked to physiological functions affecting energy metabolism. Brain ABHD6 degrades 2-arachidonoylglycerol and thereby modifies cannabinoid receptor signalling. However, its functional role within mesoaccumbens circuitry critical for motivated behaviour considerably modulated by endocannabinoids was unknown. Using three viral approaches, we show that control of the nucleus accumbens neuronal key determinant body weight reward-directed in male mice....