About
Contact & Profiles
A5094167144
Research Areas
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- Liver Disease and Transplantation
- Neuroinflammation and Neurodegeneration Mechanisms
Centro de Investigacion Principe Felipe
2024
Enhanced GABAergic neurotransmission contributes to impairment of motor coordination and gait cognitive function in different pathologies, including hyperammonemia hepatic encephalopathy. Neuroinflammation is a main contributor enhancement through increased activation pathways. For example, enhanced the TNFα–TNFR1-NF-κB-glutaminase-GAT3 pathway TNFα-TNFR1-S1PR2-CCL2-BDNF-TrkB cerebellum hyperammonemic rats enhances neurotransmission. This mediated by mechanisms affecting GABA synthesizing...
10.3389/fphar.2024.1358323
article
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cc-by
Frontiers in Pharmacology
2024-03-15
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