A5006876350- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Oral and gingival health research
- Respiratory viral infections research
- Oral microbiology and periodontitis research
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Malaria Research and Control
- Multicomponent Synthesis of Heterocycles
- Microwave-Assisted Synthesis and Applications
- Fungal Plant Pathogen Control
- Insect and Pesticide Research
- Click Chemistry and Applications
- Electrospun Nanofibers in Biomedical Applications
- Virus-based gene therapy research
- HIV/AIDS oral health manifestations
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Enzyme Production and Characterization
- SARS-CoV-2 and COVID-19 Research
- Synthesis of Tetrazole Derivatives
AIMST University
2022-2025
Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is a novel immunotherapy targeting cancer cells via the generation of chimeric receptors on NK which recognize specific antigens. CAR-NK gaining attention nowadays owing to ability release potent cytotoxicity against without side effects such as cytokine syndrome (CRS), neurotoxicity and graft-versus-host disease (GvHD). do not require priming, thus enabling them be used “off-the-shelf” therapy. Nonetheless, still possesses...
The global threat posed by recent respiratory viruses necessitates the development of novel antiviral agents. This study focused on design, synthesis, characterization and cytotoxicity evaluation two new coumarin analogues, 4-((5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)methoxy)-2H-benzopyrone (4) N-(4-chloro-benzylidene)-2-((2H-benzopyrone-4-yl)oxy)acetohydrazide (5). These compounds were synthesized from hydrazide derivative benzopyrone (3) through reactions with 4-hydroxybenzoic acid...
Periodontal disease (PD) is complex polymicrobial which destroys tooth-supporting tissue. Although various synthetic inhibitors of periodontitis-triggering pathogens have been recognized, their undesirable side effects limit application. Hence, the present study intended to perform synthesis, characterization, antimicrobial evaluation, and cytotoxicity analysis novel benzamidine analogues (NBA). This involved synthesis imino bases (4a-c), by reacting different aromatic aldehydes with...
Periodontal disease (PD) is multifactorial oral that damages tooth-supporting tissue. PD treatment includes proper hygiene, deep cleaning, antibiotics therapy, and surgery. Despite the availability of basic treatments, some these are rendered undesirable in due to side effects expense. Therefore, aim present study develop novel molecules combat triggering pathogens. The involved synthesis 4-((5-(substituted-phenyl)-1,3,4-oxadiazol-2-yl)methoxy)benzamidine (5a-e), by condensation...
Gingipains (RgpA, RgpB, and Kgp) are major virulence factors of the periodontitis-causing bacterium Porphyromonas gingivalis. Isolation gingipains from crude protein sample P. gingivalis is critical for studying underlying invasion mechanism that contributes to periodontitis, Alzheimer’s disease, cardiovascular disease (CVD). Chromatographic processes molecular cloning two standard techniques often used isolation, which time-consuming costly. In this study, considerably easier methods based...
World Health Organization (WHO) report suggests that dengue the life-threatening disease currently has no specific medication. Hence, present study was intended to synthesize some new nucleoside analogues (NNAs) combat virus (DENV-2). Study involved synthesis of 1-(4-((substituted cyclohexyl)methyl)-2-(3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-3,5-dihydroxy-1,2,4- triazinan-1-yl)ethanone (3a-f) by hydrogenation and acetylation 4-((substituted-cyclohexa-2,5-...
In silico designing of new chemical moieties to develop as active therapeutic agents is a continuous process. COVID-19 pandemic realized coronaviruses pose significant global health threat. Current study presents in antiviral potential novel coumarin analogues (NCAs) against through molecular docking analysis (MDA) and quantitative structure-activity relationship (QSAR) analysis. This explores the binding affinity relationships NCAs, focusing on their interaction with SARS-CoV-2 spike...
The oral microbiome comprises several hundreds of bacterial species that contribute to periodontitis, the most complex polymicrobial inflammatory disorder.Porphyromonas gingivalis is a prominent periodontitis pathogen produces gingipains as major virulent factor.Gingipain facilitates P. survival, pathogenicity, and growth.Several genes were identified have role in regulating pathogenesis.Studies suggest inhibition key for successful treatment periodontitis.As now, gingipain inhibitors been...
Background: Human umbilical cord mesenchymal stem cells (hUCMSCs) represent a valuable and versatile cell type derived from the tissue of newborns. These exhibit diverse characteristics, including multipotent differentiation potential low immunogenicity. hUCMSCs hold promise for clinical applications, yet concerns persist regarding their chromosomal stability. This study employs short tandem repeat (STR) analysis to assess genomic integrity. By focusing on stability, aims enhance confidence...
Coronaviruses have emerged as a global health challenge, with the recent outbreak of SARS-CoV-2 affecting more than 600 million individuals worldwide. While vaccination remains central preventive approach, addressing involves antiviral drugs, monoclonal antibodies, and corticosteroids. Research indicates that coumarin exhibits potent properties. Therefore, this study aimed to investigate properties newly synthesized analogues (NCA) against coronaviruses. The involved synthesis NCAs through...
Periimplantitis (PI) is complex polymicrobial disease, which destroys implant-supporting tissue. Although facts suggest several synthetic inhibitors of periimplantitis causing bacteria (PCB), but the undesirable side effects them limits their application. Hence, current investigation was intended to carry out synthesis, characterization, in vitro antimicrobial evaluation and cytotoxicity (cell viability) analysis new benzamidine derivatives (NBDs) against bacteria. Present study involved...
Oral squamous cell carcinoma (OSCC) developed from mucosal lining of oral cavity is ranked as 6th most common cancer worldwide. Adverse effects available anticancer agents intended present work to carry out the synthesis, characterization and evaluation new quinoline analogues (NQA) against OSCC lines. In study, substituted (1) was treated with ethyl chloroacetate offer ester derivative (2), which on treatment hydrazine hydrate yielded hydrazide (3), cyclized into oxadiazole (4) when...