Alessio Macorano

ORCID: 0009-0008-2743-1827
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About
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Research Areas
  • Antioxidant Activity and Oxidative Stress
  • Caveolin-1 and cellular processes
  • Protein Structure and Dynamics
  • Glycosylation and Glycoproteins Research
  • Bee Products Chemical Analysis
  • Phytochemicals and Antioxidant Activities
  • Computational Drug Discovery Methods
  • Monoclonal and Polyclonal Antibodies Research
  • Analytical Chemistry and Chromatography

University of Milan
2023-2024

Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE), are intricate compounds composed of interconnected flavan-3-ol units. Renowned for their health-affirming properties, PACs offer a shield against spectrum inflammation associated diseases, such as diabetes, obesity, degenerations and possibly cancer. While monomeric dimeric undergo some absorption gastrointestinal tract, larger oligomeric polymeric counterparts not bioavailable. However, higher molecular...

10.1016/j.redox.2023.102981 article EN cc-by Redox Biology 2023-12-07

In silico prediction of xenobiotic metabolism is an important strategy to accelerate the drug discovery process, as candidate compounds often fail in clinical phases due their poor pharmacokinetic profiles. Here we present Meta

10.1038/s41597-024-03707-0 article EN cc-by Scientific Data 2024-08-27

We describe a facile method to prepare water-compatible molecularly imprinted polymer nanogels (MIP NGs) as synthetic antibodies against target glycans. Three different phenylboronic acid (PBA) derivatives were explored monomers for the synthesis of MIP NGs targeting either α2,6- or α2,3-sialyllactose, taken oversimplified models cancer-related sT and sTn antigens. Starting from commercially available 3-acrylamidophenylboronic acid, also its 2-substituted isomer 5-acrylamido-2-hydroxymethyl...

10.1002/chem.202401232 article EN cc-by-nc-nd Chemistry - A European Journal 2024-06-07
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