A5020549230- Marine Invertebrate Physiology and Ecology
- Marine Ecology and Invasive Species
- Quantum chaos and dynamical systems
- Planarian Biology and Electrostimulation
- Protist diversity and phylogeny
- Coral and Marine Ecosystems Studies
- Stochastic processes and financial applications
- Zebrafish Biomedical Research Applications
- Statistical Mechanics and Entropy
- Hippo pathway signaling and YAP/TAZ
- CRISPR and Genetic Engineering
- Complex Systems and Time Series Analysis
- Muscle Physiology and Disorders
- Image and Signal Denoising Methods
- Mathematical and Theoretical Analysis
- Fluid Dynamics and Turbulent Flows
- Fractional Differential Equations Solutions
- Model Reduction and Neural Networks
- Microbial Community Ecology and Physiology
- Pluripotent Stem Cells Research
University of Vienna
2022-2024
Technical University of Munich
2015
Communication in bilaterian nervous systems is mediated by electrical and secreted signals; however, the evolutionary origin relation of neurons to other secretory cell types has not been elucidated. Here, we use developmental single-cell RNA sequencing cnidarian Nematostella vectensis, representing an early lineage with a simple system. Validated transgenics, demonstrate that neurons, stinging cells, gland cells arise from common multipotent progenitor population. We identify conserved...
Abstract Background The recent combination of genomics and single cell transcriptomics has allowed to assess a variety non-conventional model organisms in much more depth. Single transcriptomes can uncover hidden cellular complexity lineage relationships within organisms. developmental atlases the sea anemone Nematostella vectensis , representative basally branching Cnidaria, provided new insights into development all types (Steger et al Cell Rep 40(12):111370, 2022; Sebé-Pedrós al....
Abstract Animals are typically composed of hundreds different cell types, yet mechanisms underlying the emergence new types remain unclear. Here we address origin and diversification muscle cells in non-bilaterian, diploblastic sea anemone Nematostella vectensis . We discern two fast slow-contracting populations, which differ by extensive sets paralogous structural protein genes. find that regulatory gene set slow cnidarian muscles is remarkably similar to bilaterian cardiac muscle, while...
In animals, stem cell populations of varying potency facilitate regeneration and tissue homeostasis. Notably, germline cells in both vertebrates invertebrates express highly conserved RNA binding proteins, such as nanos , vasa piwi . regenerative these genes are also expressed somatic cells, which led to the proposal that they had an ancestral role all cells. cnidarians, multi- pluripotent interstitial have only been identified hydrozoans. Therefore, it is currently unclear if cnidarian...
We perform a numerical approximation of coherent sets in finite-dimensional smooth dynamical systems by computing singular vectors the transfer operator for stochastically perturbed flow. This is obtained solution discretized Fokker-Planck equation. For implementation, we employ spectral collocation methods and an exponential time differentiation scheme. experimentally compare our approach with more classical method Ulam that based on discretization unperturbed
SUMMARY Communication in bilaterian nervous systems is mediated by electrical and secreted signals, however, the evolutionary origin relation of neurons to other secretory cell types has not been elucidated. Here we use developmental single RNA-sequencing cnidarian Nematostella vectensis , representing an early lineage with a simple system. Validated transgenics, demonstrate that neurons, stinging cells, gland cells arise from common multipotent progenitor population. We identify conserved...
Abstract Background The recent combination of genomics and single cell transcriptomics has allowed to assess a variety non-conventional model organisms in much more depth. Single transcriptomes can uncover hidden cellular complexity lineage relationships within organisms. developmental atlases the sea anemone Nematostella vectensis , representative basally branching Cnidaria, provided new insights into development all types (1,2). However, mapping reads still suffers from relatively poor...
Abstract In all animals, stem cell populations of varying potency facilitate regeneration and tissue homeostasis. Notably, germline cells in both vertebrates invertebrates express highly conserved RNA-binding proteins, such as nanos, vasa piwi . Interestingly, which are capable whole-body regeneration, poriferans, hydrozoans planarians, these genes also expressed somatic multi- pluripotent cells, led to the proposal that they had an ancestral role cells. While interstitial have been...
We perform a numerical approximation of coherent sets in finite-dimensional smooth dynamical systems by computing singular vectors the transfer operator for stochastically perturbed flow. This is obtained solution discretized Fokker-Planck equation. For implementation, we employ spectral collocation methods and an exponential time differentiation scheme. experimentally compare our approach to more classical method Ulam that based on integration exact operator.