A5071614238- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Nicotinic Acetylcholine Receptors Study
- Autism Spectrum Disorder Research
- Neuropeptides and Animal Physiology
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
Brigham Young University
2020-2024
Striatal dopamine release is key for learning and motivation composed of subregions including the dorsal striatum (DS), nucleus accumbens core, shell. Spontaneously occurring was compared across these subregions. Dopamine release/uptake dynamics differ striatal subregions, with transient amplitude frequency greatest in male mice, largest signals observed DS. Surprisingly, female mice exhibited little regional differences DS core regions, but lower Blocking voltage-gated K+ channel (Kv...
Ivermectin (IVM) is a commonly prescribed antiparasitic treatment with pharmacological effects on invertebrate glutamate ion channels resulting in paralysis and death of invertebrates. However, it can also act as modulator some vertebrate has shown promise facilitating L-DOPA preclinical models Parkinson's disease. The IVM dopamine terminal function were tested, focusing the role two IVM's potential targets: purinergic P2X4 nicotinic acetylcholine receptors. enhanced electrochemical...
Abstract Previous studies indicate that moderate‐to‐high ethanol (EtOH) concentrations enhance dopamine (DA) neurotransmission in the mesolimbic DA system from ventral tegmental area (VTA) and projecting to nucleus accumbens core (NAc). However, voltammetry demonstrate EtOH decrease evoked release at NAc terminals. The involvement of γ‐aminobutyric acid (GABA) receptors (GABA A Rs), glycine (GLY) (GLYRs) cholinergic interneurons (CINs) mediating inhibition were examined. Fast scan cyclic...
Opioid use and withdrawal evokes behavioral adaptations such as drug seeking anxiety, though the underlying neurocircuitry changes are unknown. The basolateral amygdala (BLA) regulates these behaviors through principal neuron activation. Excitatory BLA pyramidal activity is controlled by feedforward inhibition provided, in part, lateral paracapsular (LPC) GABAergic inhibitory neurons, residing along BLA/external capsule border. LPC neurons express µ-opioid receptors (MORs) potential targets...
Abstract Ivermectin (IVM) is a commonly prescribed antiparasitic treatment with pharmacological effects on invertebrate glutamate ion channels resulting in paralysis and death of invertebrates. However, it can also act as modulator some vertebrate has shown promise facilitating L-DOPA preclinical models Parkinson’s disease. The IVM dopamine terminal function were tested, focusing the role two IVM’s potential targets: purinergic P2X4 nicotinic acetylcholine receptors. enhanced electrochemical...