A5017793006- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Pituitary Gland Disorders and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Microtubule and mitosis dynamics
- Health Systems, Economic Evaluations, Quality of Life
- Childhood Cancer Survivors' Quality of Life
- PI3K/AKT/mTOR signaling in cancer
- Biotechnology and Related Fields
- Pharmaceutical Economics and Policy
- Skin and Cellular Biology Research
- CRISPR and Genetic Engineering
- Cancer survivorship and care
- Growth Hormone and Insulin-like Growth Factors
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- RNA regulation and disease
- Fungal and yeast genetics research
- DNA and Nucleic Acid Chemistry
- Genomic variations and chromosomal abnormalities
- Glioma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Plant Reproductive Biology
- Genomics and Chromatin Dynamics
Jazz Pharmaceuticals (United States)
2024-2025
Rhythm (United states)
2024-2025
Royal London Group (United Kingdom)
2016
Inserm
1987-1991
Princeton University
1991
Hôpital Lariboisière
1989
Several oligonucleotide mixtures corresponding to a 6-amino acid sequence that is strictly conserved in all the ras and ras-related proteins (from various organisms) were tested for their ability hybridize 11 cloned members of gene superfamily. Among these mixtures, combination two sets partially complementary oligomers able sequences. To identify superfamily, we screened rat brain cDNA library with probes isolated four genes, denoted rab1, -2, -3, -4, encoding homologous yeast YPT protein....
Seven cDNA clones corresponding to the rabl, rab2, rab3A, rab3B, rab4, rab5, and rub6 genes were isolated from a human pheochromocytoma library.They encode 23-25 kDa polypeptides which share =30-50% homology belong ras superfamily.The rub4 proteins are counterparts of rat rub gene products that we have previously characterized.Comparison seven with yeast YPTl (YPTlp) SEC4 (SEC4p) reveals highly significant sequence similarities.H-rablp shows 75% amino acid identity YPTlp may be therefore...
After years of research and development, gene therapies are now becoming a commercial reality with several products approved by European regulatory authorities [...].
Abstract Survivors of sellar/suprasellar tumors involving hypothalamic structures face a risk impaired quality life, including tumor- and/or treatment-related obesity (TTR-HO) defined as abnormal weight gain resulting in severe persistent due to physical, treatment related damage the hypothalamus. We analyze German claims data better understand pathways for patients living TTR-HO during two years following index surgical treatment. A database algorithm identified with representative payer...
Journal Article Complete coding sequences of the ras related rab 3 and 4 cDNAs Get access Ahmed Zahraoui, Zahraoui INSERM U.248, Faculté de Médecine Lariboisière Saint-Louis10 Avenue Verdun, 75010 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Nicolas Touchot, Touchot Pierre Chardin, Chardin Armand Tavitian Nucleic Acids Research, Volume 16, Issue 3, 11 February 1988, Page 1204, https://doi.org/10.1093/nar/16.3.1204 Published: 1988 history...
Journal Article Nucleotide sequence of a rat cDNA: RAB1B, encoding RAB1-YPT related protein Get access E. Vielh, Vielh Faculté de Médecine, Lariboisiére Saint-Louis10 avenue Verdun, 75010 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Touchot, Touchot A. Zahraoui, Zahraoui Tavitian Nucleic Acids Research, Volume 17, Issue 4, 25 February 1989, Page 1770, https://doi.org/10.1093/nar/17.4.1770 Published: 1989 history Received: 17 January
GTP binding protein; Superfamily, ras ; Secretion
Abstract Hypothalamic obesity (HO) is defined as abnormal weight gain resulting in severe persistent due to physical, tumor‐ and/or treatment‐related damage the hypothalamus. HO epidemiology poorly understood. We developed a database algorithm supporting standardized identification of tumor/treatment‐related (TTR‐HO) patients. The used estimate incidence rates TTR‐HO patients German healthcare context from representative claims ( n = 5.42 million) covering 2010–2020. Patients were identified...
Abstract We have examined the expression in mouse nervous system of three new members ras protooncogene family: rab1, rab2 , and rab3 . Each these genes was transcribed into messenger RNAs with different molecular weights. These transcripts had specific developmental regional patterns expression. In particular, for genes, ratio between heavy light mRNAs depended strongly on stage brain region. The use pure neuronal glial cultures revealed that high weight were enriched neurons that, case...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)