Kounsar N. Sheikh

ORCID: 0009-0008-7294-9924
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About
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Research Areas
  • Synthesis and biological activity
  • Multicomponent Synthesis of Heterocycles
  • Analytical Chemistry and Sensors
  • Molecular Sensors and Ion Detection
  • Synthesis and Biological Evaluation
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Electrochemical sensors and biosensors
  • Enzyme function and inhibition
  • Synthesis and Characterization of Heterocyclic Compounds

Abstract This study outlines the synthesis of pyrazine sulfonamides ( 3 a – i ) along with halo‐phenyl derivatives 4 j and 5 e ). The antiproliferative effects were tested against MCF‐7 breast cancer, colon carcinoma HT‐29, HCT‐116 WT, p53 knock‐out mutant cell lines. Compounds b c notably active WT cells, while h moderately effective cells. Among sulfonamides, 4e 4j was most promising compounds evaluated non‐tumorigenic demonstrating cancer selectivity. b, c, e, , showed dose‐dependent...

10.1002/slct.202402195 article EN ChemistrySelect 2024-10-29
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