A5039594799- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Science and Education Research
- Chronic Lymphocytic Leukemia Research
- DNA Repair Mechanisms
- Chronic Myeloid Leukemia Treatments
- Telomeres, Telomerase, and Senescence
- Childhood Cancer Survivors' Quality of Life
- Hematological disorders and diagnostics
- Intestinal and Peritoneal Adhesions
- Sepsis Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Prenatal Screening and Diagnostics
- Child Nutrition and Feeding Issues
- Hematopoietic Stem Cell Transplantation
- Protein Degradation and Inhibitors
- Genomic variations and chromosomal abnormalities
- Magnesium in Health and Disease
- Cancer-related Molecular Pathways
- Medical Imaging and Pathology Studies
- Neutropenia and Cancer Infections
- Multiple Myeloma Research and Treatments
- Parathyroid Disorders and Treatments
- Advanced Breast Cancer Therapies
Universidade Federal do Pará
2020-2024
Hospital Geral de Bonsucesso
2020-2022
Abstract Aurora kinases (AURKA and AURKB) are mitotic with an important role in the regulation of several events, hematological malignancies, AURKA AURKB hyperexpression found patients cytogenetic abnormalities presenting a unfavorable prognosis. The aim this study was evaluated mRNA expression profile pediatric Acute Lymphoblastic Leukaemia (ALL) efficacy two designed inhibitors (GW809897X GW806742X) leukemia cell line as potential novel therapy for ALL patients. Cellular experiments...
Acute Lymphoblastic Leukemia (ALL) is a neoplasm of the hematopoietic system defined as clonal expansion an abnormal lymphoid precursor cell. It mostly affects children under five years age and most common tumor to afflict pediatric patients. The expression human telomerase gene (hTERT) in patients with ALL has been studied biomarker could become new therapeutic target. We evaluate role hTERT patients, through quantitative real-time PCR technique, possible correlation between clinical...
Copy number variations (CNVs) analysis may reveal molecular biomarkers and provide information on the pathogenesis of acute lymphoblastic leukemia (ALL). We investigated gene copy in childhood ALL by microarray select three new recurrent CNVs to evaluate real-time PCR assay: DMBT1, KIAA0125 PRDM16 were selected due high frequency samples based their potential biological functions carcinogenesis described literature. DBMT1 deletion was associated with patients chromosomal translocations is a...
Abstract Background Acute Lymphoblastic Leukemia (ALL) is a neoplasm of the hematopoietic system characterized by clonal expansion abnormal lymphocyte precursor cells. ALL most common form cancer in children, but despite advances treatment, it can still be fatal. Ethnic differences influence survival rates, and genomic ancestry plays an important role, especially mixed-race populations such as Latin America. This study aims to analyze on toxicity children with Amazon region. Methods The...