A5077347833- Medical Imaging and Pathology Studies
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Pleural and Pulmonary Diseases
- Angiogenesis and VEGF in Cancer
- Fibroblast Growth Factor Research
- Occupational and environmental lung diseases
- RNA modifications and cancer
- PARP inhibition in cancer therapy
- Prostate Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Cancer-related gene regulation
- Diabetes and associated disorders
- Lung Cancer Treatments and Mutations
- Chemokine receptors and signaling
- Digestive system and related health
- Aortic aneurysm repair treatments
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Tumors and Oncological Cases
- Radiopharmaceutical Chemistry and Applications
Instituto Nacional de Cancerología
2014
The University of Texas MD Anderson Cancer Center
1993-1999
We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, -gamma) on production basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The cell metastatic line SN12PM6 was established in culture from a lung metastasis SN12PM6-resistant cells were selected vitro for resistance to antiproliferative effects IFN-alpha or IFN-beta. IFN-beta, but not IFN-gamma, down-regulated expression bFGF at mRNA protein levels mechanism independent their effects....
Cutaneous infantile hemangioma progresses through proliferation and involution phases. Since treatment with interferon, a negative regulator of angiogenesis, accelerates the phase, we hypothesized that cutaneous is associated an imbalance between endogenous positive regulators angiogenesis. We examined 30 specimens [proliferative phase (n=15), involuting (n=8), involuted (n=7)] control human skin (n=17), fixed in formalin embedded paraffin. Routine histology, immunohistochemistry, mRNA situ...
PURPOSE Renal cell carcinoma (RCC) accounts for 2%-3% of adult cancers globally. In Argentina, RCC is the fifth most common cancer, with over 2,000 new patients annually. This study aims to evaluate treatment trends metastatic renal (mRCC) in Argentina. METHODS A retrospective was conducted involving 689 mRCC treated Argentina between 2015 and 2022. The analyzed patterns outcomes time. RESULTS Access combination treatments has increased significantly, 87% receiving such therapies during...
We describe the development of a rapid colorimetric in situ hybridization technique utilizing oligonucleotide probes labeled with six biotin molecules at 3' end to detect mdr1 mouse colon cancer cells growing culture and vivo. mRNA integrity was verified by use multibiotinylated poly d(T) oligonucleotide, specificity reaction confirmed sense anti-sense serial cryostat sections cultured cells. The multiple label produced strong signal after short time. Avidin-alkaline phosphatase detection...
PURPOSE This study aims to describe genomic characteristics of patients with metastatic prostate cancer (mPC). PATIENTS AND METHODS is a retrospective, multicenter cohort mPC and reports on testing. Patients were included from 12 academic centers in five countries. RESULTS A total 349 PC this study. Most (209, 59.9%) de novo metastatic. Genomic analysis was performed 233 (66.6%) the castration-resistant (mCRPC) setting, only 115 (32.8%) had tumor evaluation hormone sensitive scenario. The...
The production of basic fibroblast growth factor (bFGF) by human renal cell carcinoma (HRCC) is associated with induction angiogenesis. Incubation HRCC cells interferon alpha (IFN-alpha) or beta (IFN-beta) downregulates the expression bFGF and, hence, purpose this study was to analyze downregulation in IFN-alpha and IFN-beta. Human SN12PM6 cultured under sparse conditions expressed 3-7-fold higher levels steady-state bFGF-specific mRNA transcripts cellular protein than did confluent...
The purpose of this study was to demonstrate by ISH the presence IL-8 mRNA, and immunohistochemistry (IHC) chemokine distribution infiltrating macrophages in subcutaneous melanomas same tumor. is a multifunctional cytokine produced melanoma cells, activated monocytes it has been shown be growth angiogenic factor for tumor cells. More recently that constitutive expression correlated directly with metastatic potential human cells nude mice. content solid as determined Western blot analysis...