A5083013562- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Neuroscience and Neural Engineering
- Cell Adhesion Molecules Research
- Vestibular and auditory disorders
- Calcium signaling and nucleotide metabolism
- Proteoglycans and glycosaminoglycans research
CellAct Pharma (Germany)
2024
Medical University of Vienna
2024
University of Tübingen
2017
St. Elisabeth-Hospital Bochum
2016
Ruhr University Bochum
2016
Although sudden sensorineural hearing loss (SSNHL) is a serious condition, there are currently no approved drugs for its treatment. Nevertheless, growing understanding that the cochlear pathologies underlie SSNHL include apoptotic death of sensory outer hair cells (OHCs) as well ribbon synapses connecting inner (IHCs) and neurites auditory nerve, designated synaptopathy. Noise-induced (NIHL) common subtype widely used to model preclinically. Here, we demonstrate single interventive...
Abstract Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Due to heterogeneity of causes for SNHL, effective treatment options remain scarce, creating an unmet need novel drugs in field otology. Cochlear implantation (CI) currently only established method restore function profound SNHL and deaf patients. The cochlear implant bypasses non-functioning hair cells (HCs) electrically stimulates neurons nerve. CI also benefits patients with residual by combined...
Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Due to heterogeneity of causes for SNHL, effective treatment options remain scarce, creating an unmet need novel drugs in field otology. Cochlear implantation (CI) currently only established method restore function profound SNHL and deaf patients. The cochlear implant bypasses non-functioning hair cells (HCs) electrically stimulates neurons nerve. CI also benefits patients with residual by combined electrical...
<title>Abstract</title> Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Due to heterogeneity of causes for SNHL, effective treatment options remain scarce, creating an unmet need novel drugs in field otology. Cochlear implantation (CI) currently only established method restore function profound SNHL and deaf patients. The cochlear implant bypasses non-functioning hair cells (HCs) electrically stimulates neurons nerve. CI also benefits patients with residual by...
Cochlear implant users with residual hearing benefit synergistically from combined electrical stimulation via the cochlear and preserved after surgery. However, direct mechanical trauma subsequent inflammation may deteriorate function. AC102, a novel otoprotective pyridoindole anti-apoptotic anti-oxidative properties significantly improved recovery following implantation when administered intratympanically prior to Additionally, AC102 exerts neurotrophic effects, possibly aiding in...