Purpose To assess the diagnostic performance of callosal angle (CA) and Evans index (EI) measures to determine their role versus automated volumetric methods in clinical radiology. Materials Methods Magnetic resonance (MR) examinations performed before surgery (within 1-5 months MR examination) 36 shunt-responsive patients with normal-pressure hydrocephalus (NPH; mean age, 75 years; age range, 58-87 26 men, 10 women) age- sex-matched Alzheimer disease (n = 34) healthy control volunteers 36)...

Recent experiments and calculations have established the transition from two-dimensional (2D) to three-dimensional (3D) structures at a cluster size of 8 12 atoms for gold cations anions. For neutral clusters, however, experimental data are scarce, existing theoretical studies disagree on 2D–3D crossover point. We present results global structure optimizations clusters Aun n = 9–13 using genetic algorithm meta-generalized density functional theory. The relative energies lowest-lying isomers...

Nonadiabatic molecular dynamics simulations suggest an excited state electron proton transfer mechanism and explain the observation of mobile hydroxyl radicals.

The first total synthesis of a chromodorolide marine diterpenoid is described. core the constructed by bimolecular radical addition/cyclization/fragmentation cascade that unites two complex fragments and forms C-C bonds four contiguous stereogenic centers (-)-chromodorolide B in single step. This coupling step initiated visible-light photocatalytic fragmentation redox-active ester, which can be accomplished presence an iridium or less-precious electron-rich dicyanobenzene photocatalyst,...

Breast cancer is the most diagnosed worldwide and remains second leading cause of death. While breast mortality has steadily declined over past decades through medical advances, an alarming disparity in emerged between African American women (AAW) Caucasian (CAW). New evidence suggests more aggressive behavior triple-negative (TNBC) AAW may contribute to racial differences tumor biology mortality. Progesterone (PRG) can exert its cellular effects either classic, non-classic, or combined...

Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic stroke. It has been demonstrated three CCM proteins (CCM1, CCM2, and CCM3) form the signaling complex (CSC) mediate angiogenic signaling. Disruption of CSC will CCMs, a consequence compromised blood-brain barrier (BBB) integrity. Due their characteristically incomplete penetrance, majority mutation carriers (presumed...

ABSTRACT Rectal neuroendocrine tumors (NETs) are rare neoplasms that usually asymptomatic and diagnosed incidentally. There limited data on the presentation management of high‐grade poorly differentiated large friable rectal NETs. We report first case an 87‐year‐old male who presented with chronic diarrhea subsequently had severe hematochezia complicated by hemorrhagic shock cardiac arrest was a 7‐cm NET. Our sheds light need to consider NETs in cases importance endoscopy‐guided biopsy...

Liver cancer, comprising hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), is a leading cause of cancer-related deaths worldwide. The liver primary metabolic organ for progesterone (PRG) PRG exerts its effects through classic nuclear receptors (nPRs) non-classic membrane (mPRs) or combination both. Previous studies have shown that the CCM signaling complex (CSC) couples both nPRs mPRs to form CmPn (CSC-mPR-PRG-nPR) network, which involved in multiple cellular pathways, including...

The stereochemical outcome of reactions chiral nucleophilic trisubstituted acetonide radicals with electron-deficient alkenes is dictated by a delicate balance between destabilizing non-bonding interactions and stabilizing hydrogen-bonding substituents on the α β carbons.

Purpose Cessation of enteral nutrition is usually a part the early stage acute pancreatitis (AP) treatment. To our knowledge, there no large database study that examines effects preexisting malnutrition on morbidities patients admitted for pancreatitis. We aimed to investigate Methods Data between 2008 and 2014 from National Inpatient Sample (NIS) was extracted. Inclusion criteria included with primary diagnosis AP using International Classification Diseases, Ninth Revision (ICD-9) codes,...

Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease that occurs anywhere along duct. The predominantly in Far East Asia and very rarely diagnosed documented western countries. IPNB presents similarly to obstructive biliary pathology; however, patients can be asymptomatic. Surgical resection lesions crucial for patient survival because precancerous transform into cholangiocarcinoma. Although potentially curative by excision with negative margins, who are need close...

Over the past 20 years, advancement of artificial intelligence (AI) and deep learning (DL) has allowed for fast sorting analysis large sets data. In field gastroenterology, colorectal screening procedures produces an abundance data through video imaging. With AI DL, this information can be used to create systems where automatic polyp detection characterization is possible. Convoluted Neural Networks (CNNs) have proven effective way increase ultimately adenoma rates. Different methods being...

Abstract Breast cancer is the most commonly diagnosed worldwide and remains second leading cause of death. While breast mortality has steadily declined over past decades through medical advances, an alarming disparity in emerged between African American women (AAW) Caucasian (CAW); new evidence suggests more aggressive behavior triple-negative (TNBC) AAW may contribute to racial differences tumor biology mortality. Progesterone (PRG) capable exerting its cellular effects either classic,...

Introduction Studies show that malnutrition can lead to worsening morbidity and mortality in patients. However, our knowledge, no large database study has been conducted describing the effects of patients with diverticulitis. In this article, we aim assess impact pre-existing on outcomes admitted for Methods Data between 2008 2014 from Nationwide Inpatient Sample were extracted. Inclusion criteria both groups included a primary diagnosis diverticulitis using International Classification...

Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a subtype of non-Hodgkin (NHL) that localized to the skin. Disseminated disease rare, and visceral organ involvement even more so. We report unique case PCALCL with gastric metastasis. A 75-year-old man history left lower extremity status post radiation therapy initially presented abdominal pain was found have diffuse celiac axis retroperitoneal lymphadenopathy. Endoscopy, done biopsy an involved lymph node (LN), demonstrated...

Soilage of the surgical endoscope occurs frequently during minimally invasive surgery. The resultant impairment visualization field compromises patient safety, prolongs operative times, and frustrates surgeons. standard practice for cleaning camera involves a disruption in conduct surgery by completely removing from field, manually its lens, treating it with surfactant, reinserting into patient; after which surgeon resumes procedure.

Sarcasm detection is a significant challenge in sentiment analysis due to the nuanced and context-dependent nature of verbiage. We introduce Pragmatic Metacognitive Prompting (PMP) improve performance Large Language Models (LLMs) sarcasm detection, which leverages principles from pragmatics reflection helping LLMs interpret implied meanings, consider contextual cues, reflect on discrepancies identify sarcasm. Using state-of-the-art such as LLaMA-3-8B, GPT-4o, Claude 3.5 Sonnet, PMP achieves...

Performance of various cognitive tasks is known to decline with normal aging. The goal this study was assess possible changes in selective attention due aging a visual search task. Each trial began fixation cross presented for 900 ms, followed by cue word (red, green, blue, or yellow) 800 and second (750 ms). Then the screen consisting 8 hollow circles aligned circular configuration, each containing grey line either vertical horizontal orientation. target circle displayed color indicated...