Agnieszka Sztyler
A5020346690- Receptor Mechanisms and Signaling
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Cancer therapeutics and mechanisms
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- RNA Research and Splicing
- Protein Kinase Regulation and GTPase Signaling
- Genetic Neurodegenerative Diseases
- Pancreatic function and diabetes
- Antibiotics Pharmacokinetics and Efficacy
- Genetics, Aging, and Longevity in Model Organisms
- Heat shock proteins research
- Lipid Membrane Structure and Behavior
- Membrane Separation Technologies
- Computational Drug Discovery Methods
- Machine Learning in Bioinformatics
- PI3K/AKT/mTOR signaling in cancer
- Graphene and Nanomaterials Applications
- Renal and related cancers
- Lung Cancer Research Studies
International Institute of Molecular and Cell Biology
2024
University of Warsaw
2018-2020
Due to the involvement of G protein-coupled receptors (GPCRs) in most physiological and pathological processes humans they have been attracting a lot attention from pharmaceutical industry as well scientific community. Therefore, need for new, high quality structures GPCRs is enormous. The updated homology modeling service GPCRM (http://gpcrm.biomodellab.eu/) meets those expectations by greatly reducing execution time submissions (from days hours/minutes) with nearly same average obtained...
Abstract G protein-coupled receptors (GPCRs) are involved in numerous physiological processes and the most frequent targets of approved drugs. The explosion number new 3D molecular structures GPCRs (3D-GPCRome) during last decade has greatly advanced mechanistic understanding drug design opportunities for this protein family. While experimentally-resolved undoubtedly provide valuable snapshots specific GPCR conformational states, they give only limited information on their flexibility...
Abstract Human and mouse genetic studies have demonstrated a role for DNA mismatch repair (MMR) molecular machines in modulating the rate of somatic expansion huntingtin ( HTT) CAG repeats, onset progression Huntington’s Disease (HD). MutSβ, key component MMR pathway, is heterodimeric protein MSH2 MSH3 that recognizes initiates extrahelical extrusions. Loss-of-function Msh3 reduced-expression alleles human lead to slower rates delayed disease humans, signifying as promising therapeutic...