A5032094809- Synthesis and Biological Evaluation
- Ferrocene Chemistry and Applications
- Cyclopropane Reaction Mechanisms
- Vanadium and Halogenation Chemistry
- Advanced biosensing and bioanalysis techniques
- Advanced battery technologies research
- Metal-Catalyzed Oxygenation Mechanisms
- Molecular Junctions and Nanostructures
Universidad de la República de Uruguay
2024
Instituto Venezolano de Investigaciones Científicas
2018
University of Carabobo
2018
Searching for new prospective drugs against Chagas disease (American trypanosomiasis) and Leishmaniasis, a series of five heteroleptic vanadium compounds, [V IV O(L-H)(mpo)], where L are 8-hydroxyquinoline derivatives mpo is 2-mercaptopyridine N -oxide, synthesized characterized. Comprehensive characterizations conducted in solid state solution. The compounds evaluated on epimastigotes trypomastigotes Trypanosoma cruzi promastigotes Leishmania infantum , alongside VERO cells, as mammalian...
Human African trypanosomiasis (HAT, sleeping sickness) and American (Chagas disease) are endemic zoonotic diseases caused by genomically related trypanosomatid protozoan parasites (Trypanosoma brucei Trypanosoma cruzi, respectively). Just a few old drugs available for their treatment, with most of them sharing poor safety, efficacy, pharmacokinetic profiles. Only fexinidazole has been recently incorporated into the arsenal treatment HAT. In this work, new multifunctional Ru(II) ferrocenyl...
Introducción: Los complejos metálicos juegan un importante papel en la lucha contra el cáncer; estos fármacos interaccionan con ADN mediante enlaces covalentes las bases nitrogenadas, provocando distorsión de hebra para su posterior reconocimiento por proteínas que inducen muerte celular. Objetivo: Caracterizar a través métodos computacionales basados Mecánica Cuántica y Molecular, interacción entre diversos anti-cancerígenos ADN. Materiales métodos: Se optimizaron todas estructuras dichos...