A5061028031- Protein Tyrosine Phosphatases
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Garlic and Onion Studies
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Hops Chemistry and Applications
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Biochemical and Molecular Research
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Synthesis and biological activity
- Medicinal plant effects and applications
- Advanced Breast Cancer Therapies
University of Wisconsin–Madison
2025
University of California, Irvine
2024
Membrane proteins play crucial roles in biological signaling and represent key targets drug discovery, garnering significant experimental computational attention. Recent advances screening techniques have enabled the development of more accurate efficient binding affinity calculation methods. Among these, Molecular Mechanics Poisson Boltzmann Surface Area (MMPBSA) method has gained widespread adoption large-scale simulations due to its efficiency. However, application membrane protein-ligand...
Membrane proteins play crucial roles in biological signaling and represent key targets drug discovery, garnering significant experimental computational attention. Recent advances screening techniques have enabled the development of more accurate efficient binding affinity calculation methods. Among these, Molecular Mechanics Poisson Boltzmann Surface Area (MMPBSA) method has gained widespread adoption large-scale simulations due to its efficiency. However, application membrane protein-ligand...
SHP2, a pivotal component downstream of both receptor and non-receptor tyrosine kinases, has been underscored in the progression various human cancers neurodevelopmental disorders. Allosteric inhibitors have proposed to regulate its autoinhibition. However, oncogenic mutations, such as E76K, convert SHP2 into open state, wherein catalytic cleft becomes fully exposed ligands. This study elucidates dynamical properties structures across different states, with focus on effects mutation two...
SHP2, a pivotal component downstream of both receptor and non-receptor tyrosine kinases, has been underscored in the progression various human cancers neurodevelopmental disorders. Allosteric inhibitors have proposed to regulate its autoinhibition. However, oncogenic mutations, such as E76K, convert SHP2 into open state, wherein catalytic cleft becomes fully exposed ligands. This study elucidates dynamic properties structures across different states, with focus on effects mutation two known...
SHP2, a pivotal component downstream of both receptor and non-receptor tyrosine kinases, has been underscored in the progression various human cancers neurodevelopmental disorders. Allosteric inhibitors have proposed to regulate its autoinhibition. However, oncogenic mutations, such as E76K, convert SHP2 into open state, wherein catalytic cleft becomes fully exposed ligands. This study elucidates dynamic properties structures across different states, with focus on effects mutation two known...