A5042978493- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Pharmacogenetics and Drug Metabolism
- Microtubule and mitosis dynamics
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Prostate Cancer Treatment and Research
- Advanced Proteomics Techniques and Applications
- Estrogen and related hormone effects
Research Institute of Molecular Pathology
2008-2017
Vienna Biocenter
2017
CeMM Research Center for Molecular Medicine
2012-2017
Austrian Academy of Sciences
2013-2017
N-terminal histone tails are subject to many posttranslational modifications that recognized by and interact with designated reader domains in histone-binding proteins. BROMO domain adjacent zinc finger 2B (BAZ2B) is a multidomain protein contains two modules, plant homeodomain (PHD) bromodomain (BRD), linked largely disordered linker. Although previous studies have reported specificity of the PHD for unmodified N terminus H3 BRD acetylated at Lys14 (H3K14ac), exact mode binding BAZ2B its...
Dynamic changes in histone post-translational modifications (PTMs) regulate gene transcription leading to fine-tuning of biological processes such as DNA replication and cell cycle progression. Moreover, specific constitute docking sites for recruitment damage repair proteins mediation subsequent survival. Therefore, understanding monitoring PTMs that can alter proliferation thus lead disease progression are considerable medical interest. In this study, stable isotope labeling with...