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Abena D. Peasah

ORCID: 0009-0009-0282-4701
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A5032758119
Research Areas
  • Genetic and Kidney Cyst Diseases
  • Hedgehog Signaling Pathway Studies
  • Epigenetics and DNA Methylation

Massachusetts Institute of Technology
 2020-2021

 An EMT–primary cilium–GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis
OPENALEX - Publications 
Molly M. Wilson Céline Callens Matthieu Le Gallo Svetlana Mironov Qiong Ding and 17 more Amandine Salamagnon Tony E. Chavarria Roselyne Viel Abena D. Peasah Arjun Bhutkar Sophie Martin Florence Godey Patrick Tas Hong Soon Kang Philippe Juin Anton M. Jetten Jane E. Visvader Robert A. Weinberg Massimo Attanasio Claude Prigent Jacqueline A. Lees Vincent J. Guen

EMT induces cilium assembly and signaling to promote mammogenesis tumorigenesis.

10.1126/sciadv.abf6063 article EN cc-by-nc Science Advances 2021-10-27
 An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis
OPENALEX - Publications 
Molly M. Wilson Céline Callens Matthieu Le Gallo Svetlana Mironov Qiong Ding and 14 more Amandine Salamagnon Tony E. Chavarria Abena D. Peasah Arjun Bhutkar Sophie Martin Florence Godey Patrick Tas Anton M. Jetten Jane E. Visvader Robert A. Weinberg Massimo Attanasio Claude Prigent Jacqueline A. Lees Vincent J. Guen

Abstract The Epithelial–Mesenchymal Transition (EMT) and primary ciliogenesis induce stem cell properties in basal Mammary Stem Cells (MaSCs) to promote mammogenesis, but the underlying mechanisms remain incompletely understood. Here, we show that EMT transcription factors at intermediate transition states by activating inducers, including FGFR1. resulting cilia BBS11-dependent ubiquitination inactivation of a central signaling node, GLIS2. We GLIS2 promotes MaSC stemness, is required for...

10.1101/2020.12.29.424695 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2020-12-29
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