A5055799663- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Boron Compounds in Chemistry
- Multicomponent Synthesis of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Radiopharmaceutical Chemistry and Applications
- Cyclopropane Reaction Mechanisms
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Boron and Carbon Nanomaterials Research
- Diamond and Carbon-based Materials Research
- Carbohydrate Chemistry and Synthesis
- Synthesis of Organic Compounds
- Synthesis and Reactivity of Heterocycles
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Pyrroles
- Synthesis of heterocyclic compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Vanadium and Halogenation Chemistry
- Synthesis and Catalytic Reactions
Taras Shevchenko National University of Kyiv
2010-2024
Enamine (Ukraine)
2009-2024
Kansas State University
2021
University of Kansas Medical Center
2021
Southern University of Science and Technology
2021
Ruhr University Bochum
2021
Freie Universität Berlin
2021
Institute of Organic Chemistry
2021
Maria Curie-Skłodowska University
2021
An efficient chlorotrimethylsilane-promoted synthetic protocol for the preparation of functionalized fused β-trifluoromethyl pyridines by cyclization electron-rich aminoheterocycles or substituted anilines with a trifluoromethyl vinamidinium salt was developed. The and scalable approach producing represented demonstrated huge prospects further use. structure specificities their impact on reaction progress were determined. procedure's scope alternative ways investigated. possibility...
An efficient two-step multigram synthesis of the previously unknown 3-benzyl-3-azabicyclo[3.1.1]heptan-6-one is described. The compound shown to be a promising building block for further selective derivatization cyclobutane ring providing novel conformationally restricted piperidine derivatives.
Cyclization of 2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate with various amino heterocycles led to the formation a series fused heterocyclic systems containing 3-formylpyridine or 5-formylpyrimidine unit.
Chlorotrimethylsilane-promoted double Mannich annulation of ketones using N,N-bis(methoxymethyl)benzylamine has been explored. It shown that the structure substrate drastically influenced outcome reaction. The method allows azabicyclo[n.3.1]alkane derivatives (n = 2-5) to be obtained in good yields.
Recyclization reactions of 5-formyl-1,3-dimethyluracil with various electron-rich five- or six-membered amino heterocycles led to the formation a series fused containing nicotinic acid unit.
Abstract The new efficient, convenient protocol for the synthesis of heteroannelated 3-cyanopyridines and pyrimidines starting from diverse aminoheterocycles 3,3-dimethoxy-2-formylpropionitrile sodium salt was elaborated. advantages improvements procedure compared to previously known methods are shown. scope limitations method determined. impact structural features on regioselectivity discussed. preparativeness, scalability, application elaborated demonstrated by five in quantities up 100 grams.
A practical synthetic procedure for the synthesis of dihydro-2H-pyran-3(4H)-one is reported.The method commenced from readily available -ketoglutaric acid and allowed preparation title compound in four steps 31% overall yield.
Pyrolyses of tetraethylammonium and tetrabutylammonium borohydrides were performed. The obtained products examined by 11B NMR spectroscopy. It was shown that formation higher boranes is extremely sensitive to the presence water vapor (2.7-2.8 kPa partial pressure). pyrolysis conditions Et4NBH4 Bu4NBH4 suitable for synthesis salts containing B3H8- B12H122- found optimized. High-yield syntheses Bu4NB3H8 (Bu4N)2B12H12 with developed.
The study shows that traditional methods for synthesizing ortho-carboranes from nido-B10H14 and its complexes (B10H12L2) using donor- acceptor-disubstituted acetylenes yielding low efficiencies (yields 0 - 12%). Attempts to improve yields with ionic liquids silver salts as catalysts were unsuccessful disubstituted acetylenes. However, it has been found the use of mono-substituted (phenylacetylene, ethyl propiolate) in presence reaction B10H12L2 substrates produces high (~90%). This suggests...
Abstract Cyclocondensation of a variety amino heterocycles with the trisformylmethane synthon (II) offers useful access to title compounds in varying yields.
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