A5073310626- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Health Systems, Economic Evaluations, Quality of Life
- Obesity and Health Practices
- Connective tissue disorders research
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Meta-analysis and systematic reviews
- Acute Ischemic Stroke Management
- Primary Care and Health Outcomes
- Anesthesia and Sedative Agents
- Intraocular Surgery and Lenses
- Cleft Lip and Palate Research
- Head and Neck Cancer Studies
- Healthcare Policy and Management
- Plant Disease Resistance and Genetics
- Cardiac Valve Diseases and Treatments
- Sperm and Testicular Function
- RNA Interference and Gene Delivery
- Aortic Disease and Treatment Approaches
- Diabetes Management and Education
- Coaching Methods and Impact
- dental development and anomalies
- Congenital heart defects research
Michigan State University
2022-2024
Michigan United
2023
University of Michigan
2016-2023
University of Utah
1996-2017
<h3>Background:</h3> Health coaching is potentially a practical method to assist patients in achieving and maintaining healthy lifestyles. In health coaching, the coach partners with patient, helping discover their own strengths, challenges, solutions. <h3>Methods:</h3> Two medical assistants were provided brief training. The 12-week program consisted of telephone in-person visits at beginning end program. Coaching targeted improvements diet, physical activity, and/or sleep habits using...
The cytoplasmic droplet is a conserved dilated area of cytoplasm situated at the neck sperm flagellum. Viewed as residual inherited from late spermatids, contains numerous saccular elements its key content. However, origin these saccules and function have long been speculative. Here, we identify molecular components by uncovering vesicle pathway essential for formation sequestration within droplet. This process governed transmembrane protein SYPL1 interaction with VAMP3. Genetic ablation in...
PIWI proteins and their associated piRNAs act to silence transposons promote gametogenesis. Murine MIWI, MILI, MIWI2 have multiple arginine glycine (RG)-rich motifs at N-terminal domains. Despite being known as docking sites for the TDRD family proteins, in vivo regulatory roles these RG directing piRNA biogenesis spermatogenesis remain elusive. To investigate functional significance of mammalian vivo, we genetically engineered an lysine (RK) point mutation a conserved motif MIWI mice. We...
Failure of palatogenesis results in cleft palate, one the most common congenital disabilities humans. During final phases palatogenesis, protective function peridermal cell layer must be eliminated for medial edge epithelia to adhere properly, which is a prerequisite successful fusion secondary palate. However, deeper understanding role and fate periderm palatal adherence has been hampered due lack appropriate periderm-specific genetic tools examine this type vivo. Here we used...
ABSTRACT PIWI-interacting RNAs (piRNAs) play critical and conserved roles in transposon silencing gene regulation the animal germline. Two distinct piRNA populations are present during mouse spermatogenesis: pre-pachytene piRNAs fetal/neonatal testes pachytene adult testes. PNLDC1 is required for both 3’ end maturation multiple species. However, whether bona fide trimmer physiological role of trimming two spermatogenesis remain unclear. Here, by inactivating Pnldc1 exonuclease activity vitro...
PIWI-interacting RNAs (piRNAs) play critical and conserved roles in transposon silencing gene regulation the animal germline. Three distinct piRNA populations are present during mouse spermatogenesis: fetal piRNAs fetal/perinatal testes, pre-pachytene pachytene postnatal testes. PNLDC1 is required for 3' end maturation multiple species. However, whether bona fide trimmer physiological role of trimming different spermatogenesis mammals remain unclear. Here, by inactivating Pnldc1 exonuclease...
Health coaching is potentially a cost‐effective method by which individuals can obtain assistance in achieving and maintaining healthy lifestyles primary care. In health coaching, the counselor partners with patient, helping patients discover their own strengths, challenges, solutions. Currently, there little research on regard to integration within care setting. The aim of this study determine whether medical assistants assist providers healthier lifestyle for patients. We recruited trained...
Calcific aortic valve disease (CAVD) is a common cardiac defect, particularly in the aging population. While several risk factors, such as bi-leaflet structure and old age, have been identified CAVD pathogenesis, molecular mechanisms resulting this condition are still under active investigation. Bone morphogenetic protein signaling via activin type I receptor (AcvRI) plays an important role during physiological pathological processes involving calcification, e.g., bone formation heterotopic...