A5069255294- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Hormonal and reproductive studies
- Cancer, Hypoxia, and Metabolism
- Thyroid Disorders and Treatments
- Sexual Differentiation and Disorders
- Ion Transport and Channel Regulation
- Congenital heart defects research
- Cardiac Arrest and Resuscitation
- Pharmacological Effects and Assays
- Hypothalamic control of reproductive hormones
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Nutritional Studies and Diet
- Urinary Bladder and Prostate Research
- Lung Cancer Treatments and Mutations
- Clinical Laboratory Practices and Quality Control
- Gut microbiota and health
- Inflammatory Bowel Disease
- Urinary Tract Infections Management
- Genetic Syndromes and Imprinting
- Lung Cancer Research Studies
- Cardiovascular Disease and Adiposity
Peking Union Medical College Hospital
2010-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Shanghai First People's Hospital
2024-2025
Shanghai Jiao Tong University
2023-2024
Central Hospital of Zibo
2024
Ruijin Hospital
2019-2023
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021
Abstract Background Despite the extensive research on data mining algorithms, there is still a lack of standard protocol to evaluate performance existing algorithms. Therefore, study aims provide novel procedure that combines algorithms and simplified preprocessing establish reference intervals (RIs), with five assessed objectively as well. Methods Two sets were derived from population undergoing physical examination. Hoffmann, Bhattacharya, Expectation Maximum (EM), kosmic, refineR combined...
ABSTRACT Objective This study aimed to evaluate the long‐term effects of hormone therapies on body composition, adipokines and metabolic parameters adult men with congenital hypogonadotropic hypogonadism (CHH). Methods Sixty‐six patients CHH 21 healthy controls were recruited. Patients divided into untreated ( n = 33) treated groups based therapy history. Body composition was assessed using dual‐energy X‐ray absorptiometry (DXA), measured in all participants. Results Compared control group,...
Abstract Background Different anesthetic drugs and techniques may affect survival outcomes for gastric cancer (GC) after surgery. In this study, we investigated the association between sedated unsedated gastroscopy on in patients with GC Methods This was a retrospective study of who were diagnosed by underwent gastrectomy from January 2013 to December 2017. They grouped based examination modality: propofol-based or gastroscopy. Propensity score matching (PSM) used balance baseline variables....
Abstract Background Compound epidermal growth factor receptor ( EGFR ) mutations are less responsive to tyrosine kinase inhibitors (TKIs) than single in non-small cell lung cancer (NSCLC). However, the detailed clinical characteristics and prognosis of various compound remain be elucidated. Methods We retrospectively studied next-generation sequencing (NGS) data treatment-naïve tumors from 1025 NSCLC patients with mutations, which were sub-categorized into different combinations common...
Abstract Aims Both hypercapnia and hypocapnia are common in patients with acute heart failure (AHF), but the association between partial pressure of arterial carbon dioxide (PaCO 2 ) AHF prognosis remains unclear. The objective this study was to investigate connection PaCO within 24 h after admission intensive care unit (ICU) mortality during hospitalization at 1 year patients. Methods results were enrolled from Medical Information Mart for Intensive Care IV database. divided into three...
Sample preparation is the rate-limiting step in liquid chromatography-mass spectrometry (LC-MS)/MS-based clinical analysis when target analytes possess significantly different properties. Repeated solid-phase extraction (SPE) processes are typically required, resulting low throughput and excessive consumption of labor, materials, samples. In this study, we developed validated a feasible productive method to enrich with properties during single operation, while sufficiently removing matrix...
To explore the effects of chronic intermittent hypoxia (CIH), which mimics sleep apnea syndrome, on cardiac renin angiotensin system (RAS), and to investigate protection an receptor blocker (ARB)telmisartan (TERT) against CIH. 32 healthy male C57B6J mice were randomly divided into CIH, ARB, blank air control groups. CIH lasted for 12 weeks. Cardiac converting enzyme (ACE), 2 (ACE 2) II (Ang II) evaluated by immunohistochemistry. Myocardial apoptosis assessed TUNEL assay myocardial cell...
Abstract Background Currently, the direct method is main approach for establishment of reference interval (RI). However, only a handful studies have described effects sample size on RI and estimation size. We describe novel when establishing RIs using transformed parametric non-parametric methods. Methods A total 3,697 healthy participants were enrolled in this study. adopted two-layer nested loop to determine RI, thyroid-related hormone as an example. The was selected calculation result...
Ectopic adrenocorticotropic hormone (ACTH) syndrome is usually caused by pulmonary and bronchial tumors rarely pheochromocytoma. To date, the majority of ACTH-secreting pheochromocytomas have been unilateral, with exception two cases. A 54-year-old male presented hypertension bilateral adrenal tumors. The patient did not report having classic cushingoid features or experience paroxysmal headaches sweating, but a slight abdominal obesity. was clinically pathologically diagnosed ectopic...
Objective: To evaluate the diagnostic value of medium dose dexamethasone androgen suppression tests (DAST) in female hyperandrogenism. Methods: DAST results were retrospectively analyzed 85 cases women with hyperandrogenism including 55 congenital adrenal hyperplasia (CAH), 10 testosterone-producing tumors and 20 polycystic ovary syndrome (PCOS) between January 1984 December 2017 Peking Union Medical College Hospital. The rate testosterone 17 hydroxyprogesterone (17OHP) evaluated. cut-off...
Objective: To evaluate the value of captopril challenge test (CCT) in diagnosis primary aldosteronism (PA). Methods: A total 674 patients [(45.0±13.7) years, men 341, women 333] admitted to Peking Union Medical College Hospital from 2000 2015 were analyzed. Among them, 222 subjects with essential hypertension (EH), 28 pheochromocytoma (PHEO), 246 idiopathic hyperaldosteronism (IHA) and 178 aldosterone producing adenoma (APA). All received CCT. 24 h urine sodium was measured partial patients....
Danni Mu, B.S., Jiadan Fang, M.S., Songlin Yu, Yichen Ma, Jin Cheng, Yingying Hu, Ailing Song, Fang Zhao, Qi Zhang, Zhihong Qi, Kui Liangyu Xia, Ling Qiu, Huijuan Zhu, Ph.D., and Xinqi Ph.D.. Ann Lab Med 2024;44:29-37. https://doi.org/10.3343/alm.2024.44.1.29
To compare the sensitivity and specificity between 24 hour urine free cortisol (24 h UFC) serum in dexamethasone suppression test (DST) diagnosis of Cushing syndrome (CS).Combined low dose DST (LDDST) high (HDDST) were carried out 67 cases CS with surgically confirmed recent 3 years(from January 2011 to November 2015). The UFC collected simultaneously for each subject compared.There disease (CD) group (n=53), ectopic adrenocorticotropic hormone (ACTH) (n=7) ACTH-independent according...
近年来，特发性肺纤维化（IPF）患者的睡眠问题逐渐受到关注。IPF患者总睡眠时间减少，睡眠效率降低，睡眠期呼吸呈浅快模式，且存在低氧血症，若与阻塞性睡眠呼吸暂停（OSA）并存则危害叠加。OSA作为IPF重要共患疾病需同时治疗，使IPF患者获益，本文阐述关于特发性肺纤维化合并阻塞性睡眠呼吸暂停临床诊治的一些新认识。.
Abstract Purpose The efficacy of the third-generation PTH assay [PTH(1–84) assay] on evaluating level among pseudohypoparathyroidism type 1 (PHP1) patients have so far been limited. Therefore, we aim to examine conformity with intact (iPTH) and ability in detecting elevated PTH(1–84) PHP1 patients. Methods iPTH were conducted patients, primary hyperparathyroidism (PHPT) group normal control group. Linear regression test was within each performance against assay. ∆PTH%, 3 rd /2 nd ratio,...