A5088230587- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Electrospun Nanofibers in Biomedical Applications
- Cellular Mechanics and Interactions
- Pluripotent Stem Cells Research
- Opportunistic and Delay-Tolerant Networks
- Tissue Engineering and Regenerative Medicine
- Blood properties and coagulation
- Mesenchymal stem cell research
- Optical Imaging and Spectroscopy Techniques
- Lipid Membrane Structure and Behavior
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Underwater Vehicles and Communication Systems
- Advanced Fluorescence Microscopy Techniques
- Energy Harvesting in Wireless Networks
- Spectroscopy and Quantum Chemical Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Biosensing Techniques and Applications
- Cell Adhesion Molecules Research
Massachusetts Institute of Technology
2012-2023
Washington University in St. Louis
2008-2012
Northwestern University
2009
Journal Article Mechanisms of tumor cell extravasation in an vitro microvascular network platform Get access Michelle B. Chen, Chen Department Mechanical Engineering, Massachusetts Institute Technology, Cambridge, MA, USA Search for other works by this author on: Oxford Academic Google Scholar Jordan A. Whisler, Whisler Jessie S. Jeon, Jeon Roger D. Kamm USADepartment Biological E-mail: rdkamm@mit.edu Integrative Biology, Volume 5, Issue 10, October 2013, Pages 1262–1271,...
The mechanical and biochemical microenvironment influences the morphological characteristics of microvascular networks (MVNs) formed by endothelial cells (ECs) undergoing process vasculogenesis. objective this study was to quantify role individual factors in determining key network parameters an effort construct a set design principles for engineering vascular with prescribed morphologies. To achieve goal, we developed multiculture microfluidic platform enabling precise control over...
Journal Article Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems Get access Jessie S. Jeon, Jeon Department Mechanical Engineering, Massachusetts Institute Technology, 77 Avenue, Cambridge, MA, USA 02139 Search for other works by this author on: Oxford Academic Google Scholar Simone Bersini, Bersini Information, Electronics and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 ItalyCell Tissue Engineering...
In recent years, microfluidic systems have been used to study fundamental aspects of angiogenesis through the patterning single-layered, linear or geometric vascular channels. vivo, however, capillaries exist in complex, three-dimensional (3D) networks, and angiogenic sprouting occurs with a degree unpredictability all x,y,z planes. The ability generate capillary beds vitro that can support thick, biological tissues remains key challenge regeneration vital organs. Here, we report engineering...
The dynamics of filopodia interacting with the surrounding extracellular matrix (ECM) play a key role in various cell-ECM interactions, but their mechanisms interaction ECM 3D environment remain poorly understood. Based on first principles, here we construct an individual-based, force-based computational model integrating four modules 1) penetration dynamics; 2) intracellular mechanics cellular and nuclear membranes, contractile actin stress fibers, focal adhesion 3) structural fiber...
Vascularization is driven by morphogen signals and mechanical cues that coordinately regulate cellular force generation, migration, shape change to sculpt the developing vascular network. However, it remains unclear whether vasculature actively regulates its own properties achieve effective vascularization. We engineered tissue constructs containing endothelial cells fibroblasts investigate mechanics of Tissue stiffness increases during morphogenesis resulting from emergent interactions...
A 2005 study by the American Society of Civil Engineers showed that six billion gallons clean, treated drinking water disappears every day, mostly due to old, leaky pipes and mains. The amount is enough serve population California. approximate dollar cost, given varied rates in different U.S. regions, $12.5 million – $92 million. Moreover, leaking systems have wasted not only dollars but also priceless natural energy resources for future generations. current research project funded US...
Lipid nanodomains in cell membranes are believed to play a significant role replication of enveloped viruses such as bird flu and HIV signaling mechanisms underlying pathological conditions cancer. However, the forces that govern formation availability these “membrane rafts” uncertain, even their existence is questioned. The central challenge no suitable imaging modalities exist (Elson, et al., 2010). We developing tools characterize visualize dynamics lipid on idealized systems called giant...