About
Contact & Profiles
A5114482922
Research Areas
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Drug Transport and Resistance Mechanisms
University of Bonn
2024
The G protein-coupled receptor 17 (GPR17) is an orphan involved in inflammatory diseases. GPR17 antagonists have been proposed for the treatment of multiple sclerosis due to their potential induce remyelination. Potent, selective are required enable target validation. In present study, we describe discovery a novel class based on anthranilic acid scaffold. compounds' potencies were evaluated calcium mobilization and radioligand binding assays, structure–activity relationships analyzed....
10.1021/acs.jmedchem.4c01755
article
EN
Journal of Medicinal Chemistry
2024-11-01
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