A5101693411- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Muscle Physiology and Disorders
- Microbial Metabolic Engineering and Bioproduction
- Blood Coagulation and Thrombosis Mechanisms
- Vitamin D Research Studies
- Cancer Immunotherapy and Biomarkers
- Inflammation biomarkers and pathways
- GDF15 and Related Biomarkers
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Photosynthetic Processes and Mechanisms
- PARP inhibition in cancer therapy
- Blood transfusion and management
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Cutaneous Melanoma Detection and Management
- Blood properties and coagulation
- Biofuel production and bioconversion
- Autoimmune Bullous Skin Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hemostasis and retained surgical items
The Ohio State University
2020-2025
Vrije Universiteit Amsterdam
2021-2023
Amsterdam University Medical Centers
2021-2023
Dutch Cancer Society
2023
Cancer Center Amsterdam
2023
University of Toronto
2016
Thrombosis and Atherosclerosis Research Institute
2013-2015
McMaster University
2014-2015
Nha Trang University
2014
University of Wisconsin–Madison
2012-2014
Activation of neutrophils by microbial or inflammatory stimuli results in the release neutrophil extracellular traps (NETs) that are composed DNA, histones, and antimicrobial proteins. In purified systems, cell-free DNA (CFDNA) activates intrinsic pathway coagulation, whereas histones promote thrombin generation through platelet-dependent mechanisms. However, overall procoagulant effects CFDNA/histone complexes as part intact NETs unknown. this study, we examined potential released from...
Objectives— Sepsis is characterized by systemic activation of inflammation and coagulation in response to infection. In sepsis, activated neutrophils extrude neutrophil extracellular traps composed cell-free DNA (CFDNA) that not only trap pathogens but also provide a stimulus for clot formation. Although the effect CFDNA on has been extensively studied, much less known about impact fibrinolysis. To address this, we (1) investigated relationship between levels fibrinolytic activity sepsis (2)...
Genome-scale metabolic models have proven useful for answering fundamental questions about capabilities of a variety microorganisms, as well informing their engineering. However, only few are available oxygenic photosynthetic particularly in cyanobacteria which and respiratory electron transport chains (ETC) share components. We addressed the complexity cyanobacterial ETC by developing genome-scale model diazotrophic cyanobacterium, Cyanothece sp. ATCC 51142. The resulting reconstruction,...
The structure of cell-free DNA (cfDNA) is altered in the blood patients with cancer. From whole-genome sequencing, we retrieve cfDNA fragment-end composition using a new software (FrEIA [fragment end integrated analysis]), as well size and tumor fraction three independent cohorts (n = 925 cancer from >10 types 321 control samples). At 95% specificity, detect 72% samples at least one measure, including 64% early-stage 220). detection correlates shorter overall (p 0.0086) recurrence-free...
Shewanella is a genus of facultatively anaerobic, Gram-negative bacteria that have highly adaptable metabolism which allows them to thrive in diverse environments. This quality makes an attractive bacterial target for research bioremediation and microbial fuel cell applications. Constraint-based modeling useful tool helping researchers gain insights into the metabolic capabilities these bacteria. However, oneidensis MR-1 only strain with genome-scale model constructed out 21 sequenced...
Article13 January 2020Open Access Source DataTransparent process Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor Sophia G Liva Division of Pharmaceutics and Pharmacology, College Pharmacy, The Ohio State University, Columbus, OH, USA Search for more papers by this author Yu-Chou Tseng Medicinal Chemistry Pharmacognosy, Anees M Dauki Michael Sovic Trang Vu Sally E Henderson Department Veterinary Biosciences, Medicine, Yi-Chiu Kuo Jason A...
ABSTRACT Background Cancer cachexia is a debilitating syndrome characterized by irreversible losses in skeletal muscle mass, with or without adipose tissue. an underrecognized that impacts ~50% of all cancer patients and accounts for up to ~20% deaths. Lung remains one the deadliest cancers United States estimated 137 000 deaths year 2021 alone. highly comorbid cachexia. Pre‐clinical models are heavily relied upon study both lung cachexia; however, there need develop novel relationship...
Objectives: Higher catabolic clearance (CL) of immune checkpoint inhibitors (ICIs) is a biomarker for less favorable outcomes, independent drug exposure, in patients with cancer, thus leading to confounded exposure-response relationships. Patients rapid mAb CL present cancer cachexia phenotypes[1,2], though underlying mechanisms linking high CL, poor response, and are poorly understood. Our previous research demonstrates elevated ICIs can be replicated mouse models cachexia, the increased...
Objective: Activation of neutrophils by microbial or inflammatory stimuli results in the release neutrophil extracellular traps (NETs) which are comprised DNA, histones, and antimicrobial proteins. In purified systems, cell-free DNA (CFDNA) activates intrinsic pathway coagulation whereas histones promote thrombin generation through platelet-dependent mechanisms. However, overall procoagulant effects CFDNA/histone complexes as part intact NETs unknown. this study, we examined potential...
Abstract Background Monoclonal antibody (mAb) immune checkpoint inhibitor (ICI) therapies have dramatically impacted oncology this past decade. However, only about one‐third of patients respond to treatment, and biomarkers predict responders are lacking. Recent ICI clinical pharmacology data demonstrate high baseline drug clearance (CL 0 ) significantly associates with shorter overall survival, independent exposure, in receiving mAb therapies. This suggests CL may outcomes from therapy,...
Abstract The structure, fragmentation pattern, length and terminal sequence of cell-free DNA (cfDNA) is under the influence nucleases present in blood. We hypothesized that differences diversity bases at end cfDNA fragments can be leveraged on a genome-wide scale to enhance sensitivity for detecting presence tumor signals plasma. surveyed termini 572 plasma samples from 319 patients with 18 different cancer types using low-coverage whole genome sequencing. fragment-end were altered all...
The neonatal Fc receptor (FcRn) is responsible for recycling of IgG antibodies and albumin throughout the body. This mechanism has been exploited pharmaceutic delivery across an array diseases to either enhance or diminish this function. Monoclonal albumin-bound nanoparticles are examples FcRn-dependent anti-cancer therapeutics. Despite its importance in drug delivery, little known about FcRn expression circulating immune cells. Through time-of-flight mass cytometry (CyTOF) we were able...
High baseline clearance of immune checkpoint inhibitors (ICIs), independent dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, therapy failure are unknown. Here, we evaluate four murine models across multiple antibodies whether altered catabolic administered antibody requires a tumor and/or medical reversal phenotype can alleviate clearance. Key findings include mild lack elevated pembrolizumab the MC38 tumor-bearing...
High baseline clearance of immune checkpoint inhibitors (ICIs), independent dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, therapy failure are unknown. Here, we evaluate four murine models across multiple antibodies whether altered catabolic administered antibody requires a tumor and/or medical reversal phenotype can alleviate clearance. Key findings include mild lack elevated pembrolizumab the MC38 tumor-bearing...
Abstract There is no formal community-wide melanoma screening program in Australia, but the importance of early detection and regular skin self-examination generally well understood. It important that individuals are able to identify key risk factors so those at high can modify their sun-related behaviours take appropriate preventative actions from a young age. Aims: 1) To evaluate accuracy self-reported pigmentation nevus phenotype compared clinical assessment, 2) examine agreement between...
<h3>Background</h3> Cancer cachexia is a multifactorial syndrome characterized by irreversible loss of skeletal muscle and adipose tissue resulting from increased catabolism metabolic activity.<sup>1</sup>Patients with are generally resistant to immune checkpoint inhibitor (ICI) therapy while also displaying elevated monoclonal antibody (mAb) catabolic clearance (CL), this CL serves as prognostic indicator overall survival, independent dose received.<sup>2 3</sup> Increased ICI replicated in...
e18648 Background: Cancer-related malnutrition and cachexia can lead to body composition changes. BCM be assessed at the third lumbar (L3) vertebra by CT, which is available as part of pre-trial evaluation. We previously found that low psoas muscle area (PMA) are associated with adverse P1 outcomes including higher rates ≥ Grade 3 toxicity (G3T). Here we evaluate relationships between comprehensive cross-sectional adipose tissue L3 on outcomes. Methods: Baseline CT scans for 82 patients...
<h3>Background</h3> Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death in United States with 5-year survival rates below 10%. PDAC commonly diagnosed after metastasis has occurred and treatment options are limited. Immune checkpoint inhibitor (ICI) monoclonal antibody (mAb) therapy shown great promise other cancers, however little efficacy been observed patients PDAC. The protein responsible for recycling IgG based mAb therapeutics like ICIs...