A5008615981- Material Dynamics and Properties
- Thermal and Kinetic Analysis
- Analytical Chemistry and Chromatography
- Adsorption, diffusion, and thermodynamic properties of materials
- Thermodynamic properties of mixtures
- Drug Solubulity and Delivery Systems
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Lignin and Wood Chemistry
- Chemical Thermodynamics and Molecular Structure
- biodegradable polymer synthesis and properties
- Advanced Cellulose Research Studies
- Spectroscopy and Chemometric Analyses
- Viral gastroenteritis research and epidemiology
- Material Properties and Processing
- Pharmaceutical studies and practices
- Computational Drug Discovery Methods
- Liquid Crystal Research Advancements
- Food composition and properties
- Spectroscopy Techniques in Biomedical and Chemical Research
- Polymer crystallization and properties
- Animal Virus Infections Studies
- Pharmaceutical Economics and Policy
Merck & Co., Inc., Rahway, NJ, USA (United States)
2010-2018
Purdue University West Lafayette
2006-2010
Duquesne University
2003-2004
Using additives is one of more recent and special methods to obtain a desirable polymorph. However, for pharmaceuticals, are usually limited structurally related organic compounds. In this study, we have shown the potential using salt additive induce crystallization metastable polymorph V flufenamic acid (FFA). Additionally, it was found that FFA undergoes rapid interface mediated polymorphic transformation. Therefore, slow evaporation method which can decrease contact solvent during chosen...
Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months age or younger a significant lower respiratory disease older adults. As various clinical preclinical candidates advance, cotton rats (Sigmodon hispidus) non-human primates (NHP) continue to play valuable role RSV vaccine development, since both animals are semi-permissive human (HRSV). However, appropriate utilization models critical avoid mis-interpretation findings....
The purpose of this study is to provide a quantitative characterization the thermal behavior amorphous organic pharmaceutical compounds across their glass transition temperature, and assess molecular mobility as function temperature time by combining theoretical simulations with experimental measurements using differential scanning calorimetry. A computational approach built on Boltzmann superposition principle nonexponential decay Adam-Gibbs theory entropic-dependent structural relaxation...
The enthalpy relaxation of amorphous salicin, used as model organic glass pharmaceutical relevance, was investigated using a combination DSC measurements and theoretical simulations. combined approach makes it possible to discern between the effect forming properties material effects thermal history experimental conditions. also facilitates an unambiguous definition time scale experiment, such that objective comparison among transition temperature values can be made. simulation provides...
The antiplasticizing effect of water on the permeability, crystallinity and mechanical properties microcrystalline cellulose (MCC) was investigated.Moisture decreases permeability octane up to a critical relative humidity (RH) 5% increases tensile strength 33% RH.The results are clear indications antiplasticization MCC by consistent with quasicrystallinity model.The different RH values can be attributed scale scrutiny measured property.Moisture induced has important implications where dry...