A5092927376- Helminth infection and control
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Animal Nutrition and Physiology
- Parasitic Infections and Diagnostics
- Synthesis and Biological Evaluation
- thermodynamics and calorimetric analyses
- Nicotinic Acetylcholine Receptors Study
- Drug-Induced Ocular Toxicity
- Genetics, Aging, and Longevity in Model Organisms
Justus-Liebig-Universität Gießen
2023-2024
Knowledge on the cell types and cell-specific gene expression of multicellular pathogens facilitates drug discovery allows gaining a deeper understanding pathogen biology. By utilizing single-cell RNA sequencing (scRNA-seq), we analyzed 19,581 cells globally prevalent parasitic flatworm, liver fluke Fasciola hepatica, which causes neglected tropical disease zoonosis known as fascioliasis. We identified 15 distinct clusters, including reproductive tract gastrodermis, report identification...
The spatial organization of gene expression dictates tissue functions in multicellular parasites. Here, we present the transcriptome a parasitic flatworm, common liver fluke Fasciola hepatica. We identify profiles and marker genes for eight distinct tissues validate latter by situ hybridization. To demonstrate power our atlas, focus on with substantial medical importance, including vaccine candidates (Ly6 proteins) drug resistance (glutathione S-transferases, ABC transporters). Several these...
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases - for example, the blood fluke infection, schistosomiasis are treated with drug praziquantel (PZQ). However, PZQ is ineffective against disease liver flukes from genus
Fascioliasis, a zoonotic disease caused by liver flukes of the genus
Abstract The spatial organization of gene expression dictates tissue functions in multicellular parasites. Here, we present the first transcriptome a parasitic flatworm, common liver fluke Fasciola hepatica. We identified profiles and marker genes for eight distinct tissues validated latter by situ hybridization. To demonstrate power our atlas, focused on with substantial medical importance, including vaccine candidates (Ly6 proteins), drug targets (β-tubulins, protein kinases) resistance...