A5065528700- Cancer Immunotherapy and Biomarkers
- Palliative Care and End-of-Life Issues
- Reliability and Agreement in Measurement
- Patient-Provider Communication in Healthcare
- Patient Dignity and Privacy
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Viral Infections and Immunology Research
- Pharmacological Receptor Mechanisms and Effects
- Lung Cancer Treatments and Mutations
- Healthcare Systems and Technology
- Tuberculosis Research and Epidemiology
- Patient Satisfaction in Healthcare
- Pharmacovigilance and Adverse Drug Reactions
- Machine Learning in Healthcare
- CAR-T cell therapy research
Massachusetts General Hospital
2023-2025
Harvard University
2025
PURPOSE Current approaches to accurately identify immune-related adverse events (irAEs) in large retrospective studies are limited. Large language models (LLMs) offer a potential solution this challenge, given their high performance natural comprehension tasks. Therefore, we investigated the use of an LLM irAEs among hospitalized patients, comparing its with manual adjudication and International Classification Disease (ICD) codes. METHODS Hospital admissions patients receiving immune...
The use of immune checkpoint inhibitors (ICIs) is increasing. Little known about the frequency late-onset immune-related adverse events (irAEs) and patient-specific risk factors associated with their development. To assess incidence persistent or de novo irAEs requiring hospitalization identify patient irAEs. This retrospective observational cohort study conducted from January 2011 to October 2022 included patients who received ICIs were hospitalized at an academic medical center. Exclusion...
Immune-related adverse events (irAEs) can cause severe morbidity and mortality, they impair treatment with immune checkpoint inhibitors (ICI). Risk factors for irAEs are not well understood.We observed cases of patients having tumor deposits in their liver lung during a workup irAEs, which led us to hypothesize that the presence an organ would increase odds developing organ. We then performed retrospective cohort study included who received ICI cancer were hospitalized between February 2011...
Diagnostic and prescribing practices in otitis media vary, audit is difficult because doctors may not see comparable cases. Seven general practitioners took part a pilot study to discover if simulated patients evoked the same diagnostic treatment responses as reveal patients. Forty-eight entered over three weeks provided data for two simulations; one included doctor's description of ear other photograph instead. Each doctor was shown sets simulations asked state his diagnosis treatment. The...
Abstract Background Immune checkpoint inhibitors (ICI) are associated with a distinct spectrum of toxicities. Data on irAE hospitalization rates and clinical course patients thoracic malignancies lacking. Methods Patients advanced malignancy treated ICI (2/2016 to 6/2021) were retrospectively identified. Demographic data confirmed hospitalizations extracted from the medical record descriptive analysis was performed. Results From February 2016 June 2021, 1312 received (monotherapy,...
e14609 Background: ICI rechallenge after irAE has become a significant clinical dilemma, with recurrence rates of 30-40% rechallenge. Here we examine factors influencing across 10-year period at the Massachusetts General Hospital (MGH), where Severe Immunotherapy Complications service is available to provide multidisciplinary expertise. Methods: We included patients admitted MGH for an from August 2011 July 2023. collected baseline demographics, regimens, and features. The choice used was...
Background: Immune-checkpoint inhibitor (ICI)-induced myocarditis is the most fatal immune-related adverse event (irAE). Early recognition and treatment of ICI associated with improved outcomes. However, current approaches to diagnosis have limitations. Open-source large language models (LLMs) are an accessible scalable method answering queries from human-generated text, therefore may assist in real-time early detection among at-risk patients. Research Question: Can a free, open-source LLM...
421 Background: Patients with solid tumors readmitted within 30 days (d) have a median overall survival of less than 90d. Decisions regarding goals care (GOC), engagement Palliative Care (PC) and further therapy are often deferred to the outpatient team leading future readmissions. Methods: A pilot virtual continuity visit (VCV) program was developed using video platform arrange meetings oncologists, inpatient teams, patients, families PC providers during hospital readmission 30d. The...