A5036572742- Legume Nitrogen Fixing Symbiosis
- Glycosylation and Glycoproteins Research
- Nematode management and characterization studies
- Virus-based gene therapy research
- Growth Hormone and Insulin-like Growth Factors
- Viral Infectious Diseases and Gene Expression in Insects
- Cassava research and cyanide
- Animal Virus Infections Studies
- Cytokine Signaling Pathways and Interactions
- Plant pathogens and resistance mechanisms
- Plant Gene Expression Analysis
- Lung Cancer Treatments and Mutations
- Protein Kinase Regulation and GTPase Signaling
- Agronomic Practices and Intercropping Systems
- Soybean genetics and cultivation
- Metabolism, Diabetes, and Cancer
- Biochemical and biochemical processes
- Plant nutrient uptake and metabolism
- DNA Repair Mechanisms
- Receptor Mechanisms and Signaling
- Photosynthetic Processes and Mechanisms
- Plant Reproductive Biology
- Cancer therapeutics and mechanisms
Shanxi Agricultural University
2024-2025
National Chiayi University
2008
Icahn School of Medicine at Mount Sinai
1992-1994
Gefitinib (Iressa(R), ZD1839) is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that blocks factor-mediated cell proliferation and extracellular signal-regulated kinases 1/2 (ERK1/2) signaling activation. Rad51 an essential component of the homologous recombination repair pathway. High level expression has been reported in chemo- or radioresistant carcinomas. We hypothesized gefitinib may enhance effects alkylating agent cisplatin- antitumor antibiotic...
Symbiotic nitrogen fixation, recognized as the most efficient assimilation system in ecosystems, is essential for soybean growth, nodulation provides critical to host cells. Soybeans thrive warm and moist environments. However, they are highly susceptible low temperatures, which impede formation development of root nodules. The genetic basis molecular mechanism underlying inhibition induced by temperatures remain unclear. In this study, we conducted a comparative transcriptomic analysis...
Soybean (Glycine max (L.) Merr.) is a crucial crop due to its high plant protein and oil content. Previous studies have shown that soybeans exhibit significant heterosis in terms of yield content However, the practical application soybean remains difficult, as molecular mechanisms underlying photoperiod-sensitive genic male sterile (PGMS) still unclear. This study characterized PGMS line 88-428BY, which under short-day (SD) conditions fertile long-day (LD) conditions. To elucidate genetic...
Soybean is an important economic oilseed crop, being rich in protein and plant oil, it widely cultivated around the world. Soybeans have been shown to establish a symbiotic nitrogen fixation (SNF) with their compatible rhizobia, resulting formation of nodules. Previous studies demonstrated critical roles phytohormones, such as abscisic acid cytokinin, process legume nodulation. The present study investigated role GmWRKY17, homolog Rosa hybrida (Rh)WRKY13 regulating immunity through cytokinin...
Nodulation is the most efficient nitrate assimilation system in ecosystem, while excessive fertilization has an increased inhibition effect; deciphering signal transduction mechanism process of utmost importance. In this study, genome-wide analyses GmCEP genes were applied to identify nodulation-related CEP genes; 22 family members identified, GmCEP6 was mainly expressed nodules and significantly responded treatment rhizobium infection, especially later stages. Overexpression CRISPR-Cas9...
Avian sarcoma virus UR2 and its associated helper virus, UR2AV , were molecularly cloned into lambda gtWES X B by using unintegrated viral DNAs. One several clones obtained. The DNA was subsequently pBR322. Both DNAs tested for their biological activity transfection onto chicken embryo fibroblasts. When cotransfected with DNA, able to induce transformation of fibroblasts a morphology similar that parental . -specific protein kinase RNA detected in the transfected cells. Transforming ( ),...
We have shown previously that the extracellular sequences of human insulin receptor (IR) and insulin-like growth factor I (IGFR) an inhibitory effect on protein tyrosine kinase (PTK) activity biological functions their respective Gag-receptor fusion proteins. To study role IGFR carboxyl sequence in modulation Gag-IGFR PTK activities, five mutants, CM1, CM2, CM3, CM4, CM5, containing deletions 17, 27, 47, 67, 88 amino acids (aa), respectively, were constructed from parental virus UIGFR...
The human insulinlike growth factor 1 (hIGF-1) receptor (hIGFR) is a transmembrane protein tyrosine kinase (PTK) molecule which shares high sequence homology in the PTK domain with insulin and, to lesser degree, ros transforming of avian sarcoma virus UR2. To assess potential hIGFR, we introduced intact and altered hIGFR into chicken embryo fibroblasts (CEF). full-length cDNA (fIGFR) was cloned UR2 retroviral vector, replacing original oncogene v-ros. fIGFR able promote CEF soft agar cause...
All cells are delimited by a plasma membrane, which constitutes permeability barrier between the intracellular compartment and extracellular milieu. Thus, ability of such to respond environmental stimuli requires appropriate machinery (both at membrane within cell) initiate physiologically relevant response.
Temperature-sensitive mutations in the avian sarcoma virus UR2 oncogene ros, encoding a receptor protein-tyrosine kinase (PTK), were identified. The Ala385-->Gly change mapping within highly conserved RDLAARN motif Ros domain was responsible for temperature-sensitive phenotype. Based on sequence homology of all known protein kinases and crystalline structure cAMP-dependent kinase, this region probably represents PTK catalytic loop. same mutation when introduced into human insulin...