Zahid Ahmad
A5103205035- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Galaxies: Formation, Evolution, Phenomena
- Neutrino Physics Research
- Astronomy and Astrophysical Research
- Radiation Detection and Scintillator Technologies
- Planetary Science and Exploration
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease Diagnosis and Treatment
- Particle Detector Development and Performance
- Child Nutrition and Water Access
- Particle physics theoretical and experimental studies
- Adaptive optics and wavefront sensing
- Dark Matter and Cosmic Phenomena
- Nuclear Structure and Function
- Diverse Aspects of Tourism Research
- Clinical practice guidelines implementation
- Market Dynamics and Volatility
- Pharmaceutical Economics and Policy
- Energy, Environment, Economic Growth
- RNA Research and Splicing
- Metabolism and Genetic Disorders
The University of Texas Southwestern Medical Center
2010-2025
Southwestern Medical Center
2021-2025
University of Central Punjab
2014-2024
COMSATS University Islamabad
2023
Variable Energy Cyclotron Centre
2021-2022
Nishtar Medical College and Hospital
2020
Calcutta Research Group
2018
Carter BloodCare
2018
Oregon Health & Science University
2017
University of Swat
2017
Background: Hypertriglyceridemia is associated with increased cardiovascular risk and may be caused by impaired lipoprotein clearance. Angiopoietin-like protein 3 (ANGPTL3) inhibits lipase activity, increasing triglycerides other lipids. Evinacumab, an ANGPTL3 inhibitor, reduced in healthy human volunteers homozygous familial hypercholesterolemic individuals. Results from 2 Phase 1 studies hypertriglyceridemic subjects are reported here. Methods: Subjects >150 but ≤450 mg/dL low-density...
The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are forefront of astrophysics and particle physics research. DUNE will study pertaining to preponderance matter over antimatter in early universe, dynamics supernovae, subtleties neutrino interaction physics, a number beyond Standard Model topics accessible powerful beam. A critical component program involves changes beam neutrinos,...
The DUNE IDR describes the proposed physics program and technical designs of Far Detector modules in preparation for full TDR to be published 2019. It is intended as an intermediate milestone on path a TDR, justifying choices that flow down from high-level goals through requirements at all levels Project. These design will enable experiment make ground-breaking discoveries help answer fundamental questions. Volume 1 contains executive summary general aims this document. remainder first...
Abstract The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at end of H4 beamline. This prototype for first far module Deep Underground Neutrino Experiment (DUNE), which will be Sandford Research Facility (SURF) Lead, South Dakota, U.S.A. incorporates full-size components as designed DUNE has an active volume 7 × 6 7.2 m 3 . beam delivers incident particles with well-measured momenta high-purity...
Background Homozygous familial hypercholesterolemia (HoFH) is a rare, treatment‐resistant disorder characterized by early‐onset atherosclerotic and aortic valvular cardiovascular disease if left untreated. Contemporary information on HoFH in the United States lacking, extent of underdiagnosis undertreatment uncertain. Methods Results Data were analyzed from 67 children adults with clinically diagnosed CASCADE (Cascade Screening for Awareness Detection) FH Registry. Genetic diagnosis was...
ProtoDUNE-SP is the single-phase DUNE Far Detector prototype that under construction and will be operated at CERN Neutrino Platform (NP) starting in 2018. ProtoDUNE-SP, a crucial part of effort towards first 10-kt fiducial mass far detector module (17 kt total LAr mass), significant experiment its own right. With liquid argon (LAr) 0.77 kt, it represents largest monolithic LArTPC to built date. It's technical design given this report.
Familial chylomicronemia syndrome (FCS) is a rare genetic disorder characterized by deficiency of lipoprotein lipase leading to extreme hypertriglyceridemia. Patients' burden illness and quality life have been poorly addressed in the literature.To understand ways which FCS impacts patients' lives.Investigation Findings Observations Captured Burden Illness Survey (IN-FOCUS) was global web-based survey open patients with FCS. questions captured information on diagnostic experience, symptoms,...
Abstract Mandibuloacral dysplasia (MAD) is an autosomal recessive disorder characterized by hypoplasia of the mandible and clavicles, acro‐osteolysis, lipodystrophy due to mutations in LMNA or ZMPSTE24 . Only six MAD patients are reported so far with limited phenotypic data available for them. Here, we report on two brothers (4 years 9‐month old) early onset whom thin skin was noted as 5 months age. Both had micrognathia, mottled hyperpigmentation, enlarged fontanelles but little evidence...
The DUNE IDR describes the proposed physics program and technical designs of far detector modules in preparation for full TDR to be published 2019. It is intended as an intermediate milestone on path a TDR, justifying choices that flow down from high-level goals through requirements at all levels Project. These design will enable experiment make ground-breaking discoveries help answer fundamental questions. Volume 3 dual-phase module's subsystems, coordination required its design,...
Patients with very severe hypertriglyceridemia (triglyceride levels ≥2000 mg/dL; 22.6 mmol/L) require aggressive treatment. However, little research exists on the underlying etiologies and management of hypertriglyceridemia.We hypothesized (i) in adults is mostly associated secondary causes (ii) most patients lack appropriate follow-up treatment.We queried electronic medical records at Parkland Health Hospital Systems for lipid measurements year 2016 identified serum triglyceride mg/dL (22.6...
The statistics of peak counts in reconstructed shear maps contain information beyond the power spectrum, and can improve cosmological constraints from measurements spectrum alone if systematic errors be controlled. We study effect galaxy shape measurement on predicted with Large Synoptic Survey Telescope (LSST). use LSST image simulator combination N-body simulations to model realistic for different models. include both noise and, first time, shapes. find that considered have relatively...
The complete 10-year survey from the Large Synoptic Survey Telescope (LSST) will image $\sim$ 20,000 square degrees of sky in six filter bands every few nights, bringing final depth to $r\sim27.5$, with over 4 billion well measured galaxies. To take full advantage this unprecedented statistical power, systematic errors associated weak lensing measurements need be controlled a level similar errors. This work is first attempt quantitatively estimate absolute and properties on shear due most...
Familial hypercholesterolemia is an autosomal-dominant disorder that often causes premature coronary artery disease. Unfortunately, familial remains largely undiagnosed.To estimate the prevalence of in a population blood donors.This analysis deidentified data from donors 16 years and older who donated to Carter BloodCare, one largest independent programs United States, between January 2002 December 2016. which serves about 8 million Texas, routinely measures total nonfasting serum...
The primary objective of this research article is to investigate the asymmetrical linkages between gold-oil-exchange rates and Bombay stock indexes by utilizing a nonlinear ARDL approach covering period from April 2003 May 2020. Time-series data divided into three different types regimes such as before crisis regime, after over entire period. Seasonality effects within series are identified through unit root analysis Philips Peron (PP), augmented dickey-fuller test (ADF), Kwiatkowski Schmidt...
The Dutch cascade screening model for FH was the most successful of such programs in world. It remains unclear whether aspects (i.e. direct engagement with probands and relatives outside usual healthcare settings) are feasible US. This is especially important since prior attempts at US have had very low rates (<10% families screened).We conducted a multi-site single-arm proof-of-concept study which US-based Foundation (a 501c3 research advocacy organization) directly engaged similar to...
A main science goal for the Large Synoptic Survey Telescope (LSST) is to measure cosmic shear signal from weak lensing extreme accuracy. One difficulty, however, that with short exposure time (≃15 s) proposed, spatial variation of point spread function (PSF) shapes may be dominated by atmosphere, in addition optics errors. While errors mainly cause PSF vary on angular scales similar or larger than a single CCD sensor, atmosphere generates stochastic structures wide range scales. It thus...
Background Black men and women are at higher risk for, suffer greater morbidity mortality from, atherosclerotic cardiovascular disease (ASCVD) compared with adults of European Ancestry (EA). patients familial hypercholesterolemia particularly high for ASCVD complications because lifelong exposure to elevated levels low‐density‐lipoprotein cholesterol. Methods Results This retrospective study analyzed prevalence factors in 808 heterozygous from 5 US‐based lipid clinics, findings versus EA...
Abstract The Russia–Ukraine conflict is a common concern and hot‐debated topic of the international community. This study aims to assess influence war refugee crisis's holistic repercussions on Polish tour operators/travel agencies; elaborate response capability managers/concerned authorities. Findings revealed that crisis negatively impacted travel agencies, managers were put under severe pressure—decreased number tourists, plummeted total revenue surged costs. findings further contribute...