A5100680017- Genomics and Chromatin Dynamics
- Bioinformatics and Genomic Networks
- Plant and Fungal Interactions Research
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Forest Ecology and Biodiversity Studies
- Genomics and Phylogenetic Studies
- Lung Cancer Treatments and Mutations
- Forest ecology and management
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
- Chromosomal and Genetic Variations
- Genetic factors in colorectal cancer
University of Southern California
2024-2025
Southern California University for Professional Studies
2024
University of Michigan
2023
Michigan Medicine
2020
Abstract Single-cell RNA sequencing technology has enabled in-depth analysis of intercellular heterogeneity in various diseases. However, its full potential for precision medicine yet to be reached. Towards this, we propose A Guided Pipeline Aid Repurposing Drugs (ASGARD) that defines a drug score recommend drugs by considering all cell clusters address the within each patient. ASGARD shows significantly better average accuracy on single-drug therapy compared two bulk-cell-based repurposing...
Dissecting tumor heterogeneity is a key to understanding the complex mechanisms underlying drug resistance in cancers. The rich literature of pioneering studies on analysis spurred recent community-wide benchmark study that compares diverse modeling algorithms. Here we present FastClone, top-performing algorithm accuracy this benchmark. FastClone improves over existing methods by allowing deconvolution subclones have independent copy number variation events within same chromosome regions. We...
Abstract In mammalian interphase cells, genomes are folded by cohesin loop extrusion limited directional CTCF barriers. This interplay leads to the enrichment of at barriers, isolation between neighboring topologically associating domains, and elevated contact frequency convergent barriers across genome. However, recent in vivo measurements present a puzzle: reported residence times for on chromatin range few minutes, while lifetimes much longer. Can observed features genome folding result...