A5006620538- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant-based Medicinal Research
- Venous Thromboembolism Diagnosis and Management
- Poisoning and overdose treatments
- Streptococcal Infections and Treatments
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Alcoholism and Thiamine Deficiency
- Bacterial Identification and Susceptibility Testing
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
- Infective Endocarditis Diagnosis and Management
University of Debrecen
2021-2024
Introduction Acute ischemic stroke (AIS) is a potentially devastating disease with high disability and mortality. Recombinant tissue plasminogen activator (rt-PA) an effective treatment 2–8% possible risk for symptomatic intracranial hemorrhage (sICH). Our aim was to investigate the factors long-term clinical outcomes of ICH in patients after rt-PA treatment. Methods Consecutive AIS, thrombolysed at Department Neurology, University Debrecen, between 1 January 2004 31 August 2016 were...
Objectives: This retrospective single-center study aimed to investigate the risk factors, outcomes and complication rates in patients older vs. younger than 80 years treated with intravenous alteplase. Methods: Data of 1,253 thrombolysed were analyzed between January 1, 2004 August 31, 2016. Vascular stroke severity based on NIHSS score, functional outcome using modified Rankin Scale (mRS), mortality symptomatic intracerebral hemorrhage (SICH) compared two subgroups (<80 ≥80 years)....
Background Non-traumatic intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and leads to a higher rate mortality as compared ischemic strokes. We aimed find out whether the thrombin generation assay (TGA) could predict outcomes in patients with ICH. Patients methods In this prospective, observational study, 87 consecutive ICH 164 healthy controls were included. Computed tomography (CT), detailed clinical investigation, laboratory investigations performed from on admission. TGA...
Bilophila wadsworthia is a Gram-negative anaerobic bacterium. In current study, it was identified in the bloodstream of 69-year-old man admitted to Neurology Clinic at University Debrecen, Clinical Centre, Hungary, for internal carotid artery stent implantation. Bacteraemia caused by B. extremely rare, with very few cases reported worldwide. This case notable because first instance which whole-genome sequencing derived from blood performed. Moreover, sequence data have been deposited public database.
Background: Non-traumatic intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and results in a higher rate mortality as compared to ischemic strokes. In the IRONHEART study, we aimed find out whether modified vitro clot lysis assay method, that includes effect neutrophil extracellular traps (NETs) might predict ICH outcomes. Patients Methods: this prospective, observational 89 consecutive non-traumatic patients were enrolled. Exclusion criteria included aneurysm rupture,...
The aim of this study was to evaluate how COVID-19 affected acute stroke care and outcome in patients with ischemic or hemorrhagic stroke. We performed a retrospective analysis on who were admitted (AIS) (ICH) from September 2020 May 2021 without COVID-19. recorded demographic clinical data, imaging parameters, functional mortality at one year. Beside descriptive statistics we χ2-probe, Mann-Witney U-test, Student t-probe multivariate testing. found 29%-reduction the number AIS cases during...
Rationale: Stroke is one of the leading causes death in all developed countries. In Hungary, more than 10,000 patients die annually due to cerebrovascular diseases according WHO Mortality Database. Of these patients, 10–15 % suffer non-traumatic intracerebral hemorrhage (ICH). ICH results a higher rate mortality as compared ischemic stroke and outcomes are difficult predict. IRONHEART study, we aim test various hemostasis parameters clinical neurophysiological examinations evaluating outcome...
Introduction: Intracerebral hemorrhage (ICH) is a devastating disease, which may lead to severe disability or even death. Although many factors influence the outcome, neurophysiological examinations might also play role in its course. Our aim was examine whether findings of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) can predict prognosis these patients. Methods: Between June 1 2017 15 2021, 116 consecutive patients with ICH were enrolled prospectively our...
Abstract Background: Stroke is a major cause of death and disability presenting with acute focal neurological symptoms vascular origin. Several other disorders may similar to stroke, referred as stroke mimics. Misdiagnosis mimics lead potentially harmful treatments, including thrombolysis. Intoxication rare, but possible mimic. We present three cases ethylene glycol poisoning mimic within the time window thrombolytic therapy. Case presentations: The first patient (54-year-old, male) had...
Stroke is a major cause of death and disability presenting with acute focal neurological symptoms vascular origin. Several other disorders may similar to stroke, referred as stroke mimics. The misdiagnosis mimics lead potentially harmful treatments, including thrombolysis. Intoxication rare, but possible, mimic. We present three cases ethylene glycol poisoning an mimic within the time window thrombolytic therapy. Two patients (a 54-year-old male 78-year-old male) had dysarthria, nystagmus,...