A5003572394- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Grit, Self-Efficacy, and Motivation
- Business, Innovation, and Economy
- SARS-CoV-2 and COVID-19 Research
- Heat shock proteins research
- COVID-19 Pandemic Impacts
- Network Security and Intrusion Detection
- Online Learning Methods and Innovations
- RNA and protein synthesis mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Signaling Pathways in Disease
- Cardiovascular Disease and Adiposity
- Iron Metabolism and Disorders
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Trace Elements in Health
- Infant Nutrition and Health
- Spam and Phishing Detection
- Animal Nutrition and Physiology
Tel Aviv University
2020-2024
Open University of Israel
2020
Baylor College of Medicine
2005
University of Florida
1984
Severe acute respiratory syndrome (SARS)-CoV-2 infection leads to severe disease associated with cytokine storm, vascular dysfunction, coagulation, and progressive lung damage. It affects several vital organs, seemingly through a pathological effect on endothelial cells. The SARS-CoV-2 genome encodes 29 proteins, whose contribution the manifestations, especially complications, is unknown. We cloned expressed 26 of these proteins in human cells characterized response overexpression each,...
TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ~60% mitochondrial proteome. In this study, we characterized a TIMM50 disease-causing mutation in human fibroblasts and noted significant decreases core protein levels (TIMM50, TIMM17A/B, TIMM23). Strikingly, deficiency had no impact on steady-state most its putative substrates, suggesting that even low functional are sufficient maintain majority complex-dependent As mutations have been linked severe...
Most mitochondrial proteins are synthesized as precursors that carry N-terminal presequences. After they imported into mitochondria, these targeting signals cleaved off by the processing peptidase (MPP). Using tandem protein Arg5,6 a model substrate, we demonstrate MPP has an additional role in preprotein maturation, beyond removal of is polyprotein precursor mitochondria and subsequently separated two distinct enzymes. This internal performed MPP, which cleaves at its N-terminus site. The...
In the intermembrane space (IMS) of mitochondria, receptor domain Tim23 has an essential role during translocation hundreds different proteins from cytosol via TOM and TIM23 complexes in outer inner membranes, respectively. This intrinsically disordered domain, which can even extend into cytosol, was shown, mostly vitro, to interact with several subunits complexes. To obtain molecular understanding this organizational hub IMS, we dissected IMS vivo. We show that interaction surface Tim50 is...
TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ∼60% mitochondrial proteome. In this study, we characterized a TIMM50 disease causing mutation in human fibroblasts and noted significant decreases core protein levels (TIMM50, TIMM17A/B, TIMM23). Strikingly, deficiency had no impact on steady state most its putative substrates, suggesting that even low functional are sufficient maintain majority complex-dependent As mutations have been linked severe...
Abstract TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ∼60% mitochondrial proteome. In this study, we characterized a TIMM50 disease causing mutation in human fibroblasts and noted significant decreases core protein levels (TIMM50, TIMM17A/B, TIMM23). Strikingly, deficiency had no impact on steady state most its putative substrates, suggesting that even low functional are sufficient maintain majority complex-dependent As mutations have been linked...
TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ∼60% mitochondrial proteome. In this study, we characterized a TIMM50 disease causing mutation in human fibroblasts, and noted significant decreases core protein levels (TIMM50, TIMM17A/B, TIMM23). Strikingly, deficiency had no impact on steady state most its substrates, challenging currently accepted dogma general role suggesting that fully functioning not for maintaining level majority proteins. As...
Introduction Hypomyelinating leukodystrophies are a group of genetic disorders, characterised by severe permanent myelin deficiency. Their clinical features include developmental delay with or without neuroregression, nystagmus, central hypotonia, progressing to spasticity and ataxia. HSPD1 encodes the HSP60 chaperonin protein, mediating ATP-dependent folding imported proteins in mitochondrial matrix. Pathogenic variants have been related number neurological phenotypes, including dominantly...
TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ~60% mitochondrial proteome. In this study, we characterized a TIMM50 disease-causing mutation in human fibroblasts and noted significant decreases core protein levels (TIMM50, TIMM17A/B, TIMM23). Strikingly, deficiency had no impact on steady-state most its putative substrates, suggesting that even low functional are sufficient maintain majority complex-dependent As mutations have been linked severe...
The COVID-19 pandemic challenged schools, requiring adaptive responses from academic leaders, particularly in decision-making and policy implementation during the shift to remote learning addressing struggling students. This study explores experiences of leaders about implementing Leveraging Program (LP) Remote Psychosocial Services for Students (RPSS) implemented a Philippine secondary school year 2020-2023. LP RPSS are combined intervention programs that aim foster students' engagement...
Abstract Most mitochondrial proteins are synthesized in the cytosol as precursors that carry N-terminal presequences. After import into mitochondria, these targeting signals cleaved off by processing peptidase MPP, giving rise to shorter mature proteins. Using tandem protein Arg5,6 a model substrate, we demonstrate MPP has an additional role preprotein maturation, beyond removal of is polyprotein precursor imported matrix and subsequently separated two distinct enzymes function arginine...