A5108850184- Parkinson's Disease Mechanisms and Treatments
- Sarcoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Phytochemistry and Biological Activities
- PARP inhibition in cancer therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Advanced Materials Characterization Techniques
- Lysosomal Storage Disorders Research
- Force Microscopy Techniques and Applications
- Nerve injury and regeneration
- Toxoplasma gondii Research Studies
- Vascular Tumors and Angiosarcomas
- Cytomegalovirus and herpesvirus research
- Lubricants and Their Additives
- Orthopedic Infections and Treatments
- Integrated Energy Systems Optimization
- Proteoglycans and glycosaminoglycans research
- Neuroscience and Neuropharmacology Research
- Fungal Biology and Applications
- Cardiac tumors and thrombi
- Power Systems and Renewable Energy
- Toxin Mechanisms and Immunotoxins
- Osteoarthritis Treatment and Mechanisms
Shaoxing Second Hospital
2017-2025
Shanghai Jiao Tong University
2010-2025
RNA-based vaccine represents an irresistible and safe immunization strategy with decreasing theoretical risks of genomic integration malignant cell transformation. To our knowledge, however, there is no report about development RNA against T. gondii infection. We have previously demonstrated that the recombinant Toxoplasma nucleoside triphosphate hydrolase-II (NTPase-II) protein able to provide protective Th1 cell-mediated immunity gondii. Herein, we evaluated immunogenic potential a...
Nasopharyngeal carcinoma (NPC) in young patients aged ≤30 years often presents as advanced disease, yet these generally have an improved prognosis compared with >30 old. The incidence of bone metastasis NPC ranges from 64‑67%, being the most common site metastases. Referred pain, which is perception pain distant stimulus site, a phenomenon mechanism remains poorly understood. present study describes rare case 25‑year‑old woman past medical history NPC. initial symptom was right anterior knee...
Parkinson's disease (PD) is the second most common neurodegenerative after Alzheimer's disease. Currently, no radical treatment available for this Harpagoside a proposed neuroprotective iridoid active ingredient that can be derived from Scrophulariae buergeriana, Scrophularia striata and Harpagophytum procumbens. The present study aimed to investigate effects of harpagoside on mitochondrial functions in rotenone-induced cell models (PD). Neuro-2A (N2A) cells were treated with rotenone...
Abstract Background The clinical background of cancer patients is complex, and the efficacy safety different poly (ADP-ribose) polymerase inhibitors (PARPis) vary greatly. Therefore, we conducted a systematic review network meta-analysis to compare six PARPis systematically evaluated differences in relevant contexts. Methods Databases (PubMed, Cochrane, Embase, etc.) were searched from Jan 1, 1980 Oct 20, 2023, for randomized trials. overall survival (OS), progression-free (PFS), grade 3-5...
Newly diagnosed cervical cancer with metastatic para-aortic lymph node (PALN) involvement is associated a significantly poor prognosis, distant metastasis being the predominant pattern of treatment failure. The programmed cell death receptor-1 (PD-1) pathway has garnered considerable attention due to its role in enabling tumor cells evade immune surveillance by eliciting checkpoint response T cells, rendering them highly refractory conventional chemotherapy. National Comprehensive Cancer...
Parkinson's disease is a chronic neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in substantia nigra pars compacta. New therapeutic approaches aiming at delaying or reversing process are under active investigations. In this work, we found that harpagoside, an iridoid purified from Chinese medicinal herb Scrophularia ningpoensis, could not only prevent but also rescue neurodegeneration MPTP/MPP(+) intoxication with promising efficacy. Firstly, cultured...
Retroperitoneal liposarcoma (RPLS) is a rare tumor that occurs in the retroperitoneal region and accounts for ~0.2% of all malignant incidence. The present study describes treatment surviving patient with RPLS recurred five times 13 years. This case has long survival time numerous relapses, which occurrence. 40‑year‑old female was admitted to Shaoxing Second Hospital (Shaoxing, China) an abdominal mass. Abdominal computed tomography (CT) scan revealed multiple recurrences abdominal, pelvic...