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A5116785392
Research Areas
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Immune responses and vaccinations
Max Planck Institute for Biology of Ageing
2025
Abstract Immune memory plays a critical role in the development of durable antimicrobial immune responses. How precisely mRNA vaccines train innate cells to shape protective host defense mechanisms remains unknown. Here we show that SARS-CoV-2 vaccination significantly establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters human monocyte-derived macrophages, suggesting epigenetic memory. However, found two consecutive vaccinations were required for persistence H3K27ac, which...
10.1038/s44320-025-00093-6
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Molecular Systems Biology
2025-03-25
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