A5044473817- T-cell and B-cell Immunology
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
University of Gothenburg
2016-2023
Region Västra Götaland
2023
Sahlgrenska University Hospital
2023
Abstract The pathogenic role and frequency of T cell subtypes in early rheumatoid arthritis are still unclear. We therefore performed a comprehensive analysis the circulating subtype pattern patients with untreated compared to healthy control subjects. Peripheral blood mononuclear cells were obtained from 26 18 age- sex-matched helper types Th0, Th1, Th2, Th17, Th1/17 nonclassic subsets defined by flow cytometry based on expression chemokine receptors CCR4, CCR6, CXCR3. Regulatory CD25+...
Abstract Objective Treatment with CTLA-4Ig blocks T-cell activation and is clinically effective in RA. However, it unknown if specific CD4+ subsets blood at baseline predict remission after CTLA-4Ig, or other biological treatments different modes of action, how treatment affects T cells patients untreated early RA (eRA). Methods This study included 60 eRA from a larger randomized trial. They were treated methotrexate combined (abatacept, n = 17), anti-IL6 receptor (tocilizumab, 21) anti-TNF...
Abstract Background Physical function is an important determinant of health-related quality life in radiographic axial spondyloarthritis patients (r-axSpA). To improve the basis effective healthcare efforts, we aimed to investigate which demographic and disease-related factors that influence Bath Ankylosing Spondylitis Functional Index (BASFI) r-axSpA overall stratified by sex. Furthermore, sought explore differences between sexes regarding separate BASFI questions also may contribute these...
To translate the Assessment of SpondyloArthritis international Society (ASAS) Health Index (HI) Environmental Factors Item Set (EFIS) into Swedish and culturally adapt it for a context, to assess construct validity version ASAS HI test-retest reliability in EFIS patients with ankylosing spondylitis (AS).