A5063034686- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Long-Term Effects of COVID-19
- Galectins and Cancer Biology
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
Fujian Medical University
2020-2025
Brandeis University
2022
Abstract Background COVID-19 is an extremely severe infectious disease. However, few studies have focused on the epidemiological and clinical characteristics of pediatric COVID-19. This study conducted a retrospective review features in children. Methods A was children with definite diagnosis mainland China using web crawler technique to collect anonymous updates published by local health authorities. Results Three hundred forty-one aged 4 days 14 years median age 7 were included. Sixty-six...
ABSTRACT The small hepatitis B surface antigen (SHBs) is the most abundant virus (HBV) protein in individuals infected with HBV, and clearance of HBV antigen, which primarily composed SHBs, considered a surrogate biomarker for achieving functional cure chronic HBV. Understanding SHBs degradation crucial its elimination targeted eradication strategies. This study demonstrates that undergoes via ubiquitin/proteasome pathway, through K48-linked ubiquitination, K122 as critical ubiquitination...
Abstract Acute myeloid leukemia (AML) cell survival and chemoresistance are influenced by the existence of bone marrow mesenchymal stem cells (BMMSCs); however, pathways which BMMSCs contribute to these processes remain unclear. We earlier revealed that methyltransferase-like 3 (METTL3) expression is significantly reduced in AML METTL3 mediates BMMSC adipogenesis promote human lines vitro. In this investigation, we evaluated function vivo. Mice exhibiting a conditional removal Mettl3 were...
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) has been identified as a crucial immune suppressor in human cancers, comparable to programmed cell death 1 ligand (PD-L1). However, the regulatory mechanisms underlying its transcriptional upregulation cancers remain largely unknown. Here, we show that transcription factors ETS-1 and ETS-2 bound Siglec-15 promoter enhance expression of hepatocellular carcinoma (HCC) cells transforming growth factor β-1 (TGF-β1) upregulated...
Abstract Arylsulfatases are lysosomal enzymes with important function in the cell metabolism. Studies have demonstrated that protein arylsulfatase B (ARSB) may play roles tumorigenesis and metastatic potential of tumor cells. However, relationship between ARSB stomach adenocarcinoma (STAD) has not yet been established. The aim this study was to investigate prognostic value cancers, particularly STAD explore underlying mechanisms. Gene expression data detailed clinical information cancer...