A5091919240- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Nerve injury and regeneration
- Neuroscience and Neural Engineering
- Genetic factors in colorectal cancer
- Electrochemical Analysis and Applications
- Computational Drug Discovery Methods
- Viral Infections and Immunology Research
Instituto Português de Oncologia Francisco Gentil
2025
IPO Porto
2025
Polytechnic Institute of Porto
2023
Rede de Química e Tecnologia
2023
Early detection of colorectal cancer (CRC) significantly improves overall prognosis and increases 5-year survival rates up to 90%. Current non-invasive screening methods for CRC, such as the Faecal Immunohistochemical Test (FIT), have some drawbacks, namely, low sensitivity a high false-positive rate. The Sialyl-Tn (STn) antigen, frequently expressed in pre-malignant lesions adenocarcinomas, has been shown be detected by novel monoclonal antibody L2A5. In this study, we explored potential...
The BDNF gene is associated with high degrees of variability in antidepressant treatments. Val66Met polymorphism widely known as a source this variability, warranting growing interest genotyping patients that undergo treatment to better suit their needs. This paper reports on an electrochemical genosensing platform, based gold electrodes, capable detecting polymorphism, through the use synthetic enzymatically labeled DNA probes for two different alleles. sensor showed promising results, and...