A5089690900- Asthma and respiratory diseases
- HIV/AIDS drug development and treatment
- Inhalation and Respiratory Drug Delivery
- Cloud Data Security Solutions
- Chronic Lymphocytic Leukemia Research
- Respiratory and Cough-Related Research
- Pharmaceutical Economics and Policy
- Advanced Data Storage Technologies
- Software-Defined Networks and 5G
- Statistical Methods in Clinical Trials
- Computer Graphics and Visualization Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Caching and Content Delivery
- Biochemical and Molecular Research
- Sentiment Analysis and Opinion Mining
- HIV Research and Treatment
- Pharmaceutical studies and practices
- Pharmacological Effects and Assays
- Wireless Networks and Protocols
- Toxin Mechanisms and Immunotoxins
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects of Natural Compounds
- Network Security and Intrusion Detection
- Sirtuins and Resveratrol in Medicine
- Analytical Methods in Pharmaceuticals
Microsoft (United States)
2023-2024
Tribhuvan University
2019-2021
GlaxoSmithKline (India)
2015-2019
Kathmandu University
2019
Institute of Engineering
2019
University of the West of England
2019
Sirtuins are a class of proteins with important physiologic roles in metabolism and inflammation. Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, activation is an unexplored therapeutic approach for the treatment ulcerative colitis (UC).Patients mild to moderately active UC were blindly randomized 50 mg 500 daily SRT2104, selective activator 8 weeks. Colonic exposure safety assessed, as well blinded endoscopic scoring disease activity by Mayo score, Simple Clinical...
Fluticasone furoate/Vilanterol trifenatate (FF/VI) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. We characterised the time-course onset and offset airway anti-inflammatory action FF/VI, as assessed by fraction exhaled nitric oxide (FeNO), compared this to A single-centre, randomised, double-blind, placebo-controlled, two-period, crossover study was undertaken in 28 steroid-naïve adults asthma. Participants FEV1 ≥ 60%...
Sustainable and cost-effective long-term storage remains an unsolved problem. The most widely used technologies today are magnetic (hard disk drives tape). They use media that degrades over time has a limited lifetime, which leads to inefficient, wasteful, costly solutions for long-lived data. This paper presents Silica: the first cloud system archival data underpinned by quartz glass, extremely resilient allows be left in situ indefinitely. hardware software of Silica have been co-designed...
To compare the systemic exposure of salbutamol following delivery from unit dose dry powder inhaler (UD-DPI) system with that Diskus® and metered (MDI).This open-label, two-part, six-way crossover, randomized single-dose study in healthy subjects evaluated three strengths (using inhalations: 3 × 150 μg [450 μg], 200 [600 250 [750 μg]) 2% drug lactose blends (1.6% 1.0% only] by weight) through UD-DPI compared Diskus MDI (600 dose). Systemic presence charcoal block was also evaluated. Primary...
Abstract This single‐dose study evaluated the bioequivalence, food effect, and safety of 2 experimental, 2‐drug, fixed‐dose formulations 50 mg dolutegravir 300 lamivudine (formulation AH formulation AK) as compared with coadministration single‐entity tablets (reference). In fasted subjects, exposure was similar to reference; however, consistently higher in AH, area under concentration‐time curve (AUC) maximum concentration (C max ) approximately 27% 28% greater than reference. Formulation AK...
A complete 2-drug regimen of dolutegravir at 50 mg and rilpivirine 25 was approved to treat HIV-1 infection in virologically suppressed patients after demonstrating acceptable efficacy tolerability. This study investigated the bioequivalence pharmacokinetics fixed-dose combination tablet compared with those separate tablets. Secondary endpoints were tolerability safety tablet. In this open-label, randomized-sequence, 2-way crossover trial, single doses (the test treatment) tablets reference...
Abstract Two bioavailability/bioequivalence studies were carried out to evaluate the pharmacokinetics of candesartan cilexetil 16‐mg tablet formulations. A pilot study was used optimize formulation and manufacturing process prior conducting definitive study. The a single‐dose, randomized, 2‐period crossover, 3‐period, 6‐sequence crossover in healthy adults. In test 24% 18% greater for C max AUC, respectively, compared with innovator product. Following optimization two formulations taken...
The software defined networking (SDN) paradigm with enhanced features of IPv6 offers flexible network management and better visibility for enhancing overall performance, manageability, security. Thus, along the deployment worldwide, SDN migration has emerged but service providers suffer from different issues when migrating their existing legacy into operable enabled networks. In this paper, we investigate affordability broadband services rural communities in context information communication...
Abstract A fixed‐dose combination (FDC) may improve patient compliance and clinical outcomes in the management of cardiovascular risk hypertensive dyslipidemic patients. The study (NCT02075619) evaluated bioavailability 2 prototype FDC tablet formulations (FDC1 FDC2) amlodipine/rosuvastatin (10 mg/20 mg) compared with coadministered reference tablets. It was a randomized, single‐dose, 3‐way crossover pilot healthy white (n = 12) Chinese adults. Three treatments (FDC1, FDC2, reference) were...
Sustainable and cost-effective long-term storage remains an unsolved problem. The most widely used technologies today are magnetic (hard disk drives tape). They use media that degrades over time has a limited lifetime, which leads to inefficient, wasteful, costly solutions for long-lived data. This paper presents Silica: the first cloud system archival data underpinned by quartz glass, extremely resilient allows be left in situ indefinitely. hardware software of Silica have been co-designed...
Legacy IPv4 networks are strenuous to manage and operate. Network operators in need of minimizing the capital operational expenditure running network infrastructure. The implementation software-defined networking (SDN) addresses those issues by expenditures long run. integrate with SDN for smooth migration towards fully functional environment. In this paper, we compare performance legacy IP routing order determine feasibility deployment Internet Service provider (ISP) network. simulation is...
The fixed-dose combination (FDC) tablet formulation of abacavir/dolutegravir/lamivudine is indicated for the treatment HIV-1 infection in adults and pediatric patients weighing ≥40 kg. Alternative formulations with acceptable palatability convenient dosing are needed children who require smaller doses have difficulty swallowing tablets.A phase 1, open-label, randomized study was conducted healthy to evaluate relative bioavailability a novel dispersible FDC abacavir 150 mg/dolutegravir 10...
FF is an inhaled corticosteroid (ICS) with higher glucocorticoid receptor (GR) affinity and greater lung retention compared to other ICS. We investigated whether these attributes confer a prolonged duration of anti-inflammatory action. This was randomised, double-blind, placebo-controlled, two-period, crossover study in 27 adults asthma (GSK Protocol 201499, NCT02712047). Following screening, subjects FEV1 ≥60% predicted, reversible airway disease FeNO >40ppb, received FF/VI 100µg/25µg or...
The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative platform that, if developed, has the potential to improve access inhaled respiratory medicines in developing countries.This study compared systemic exposure of fluticasone furoate after delivery from UD-DPI with that ELLIPTA® inhaler.This open-label, five-way cross-over, randomized, single-dose healthy subjects evaluated three strengths (using four inhalations), 4 × 80 μg [320 μg], 100 [400 and 140 [560 μg]), two...
Sentiment classification is an important process in understanding people's perception towards a product, service, or topic.Many natural language processing models have been proposed to solve the sentiment problem.However, most of them focused on binary classification.In this paper, we use promising deep learning model called BERT fine-grained task.Experiments show that our outperforms other popular for task without sophisticated architecture.We also demonstrate effectiveness transfer process.