A5021692656- Pancreatic function and diabetes
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Computational Drug Discovery Methods
- Neuroendocrine Tumor Research Advances
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Metabolism, Diabetes, and Cancer
First Affiliated Hospital of Wannan Medical College
2022-2025
Wannan Medical College
2023-2025
Background: Propylthiouracil (PTU) treats hyperthyroidism and thyroid crisis in all age groups. A variety of serious adverse effects can occur during clinical use require attention to its pharmacokinetic pharmacodynamic characteristics various populations. Objective: To provide information for individualized dosing evaluation PTU the setting by developing a physiologically based (PBPK) model, predicting ADME characteristics, extrapolating elderly pediatric Methods: Relevant databases...
Glucokinase (GK) plays a pivotal role in maintaining glucose homeostasis; globalagliatin, newly developed drug, is GK activator (GKA). This study constitutes randomized, open-label, two-cycle, two-crossover, single-dose, phase I clinical trial conducted at single center with healthy Chinese volunteers, aiming to examine the influence of high-fat meal on pharmacokinetics (PK) orally administered globalagliatin. Twenty-four volunteers were randomly divided into two groups, washout period 16...