A5011329661- Cell death mechanisms and regulation
- interferon and immune responses
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- CRISPR and Genetic Engineering
- Erythrocyte Function and Pathophysiology
- HER2/EGFR in Cancer Research
- Eicosanoids and Hypertension Pharmacology
- Circadian rhythm and melatonin
- Inflammatory Myopathies and Dermatomyositis
- DNA Repair Mechanisms
- RNA modifications and cancer
- Systemic Sclerosis and Related Diseases
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- NF-κB Signaling Pathways
- Cardiac Fibrosis and Remodeling
- Phagocytosis and Immune Regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- GDF15 and Related Biomarkers
- Inflammasome and immune disorders
- RNA Interference and Gene Delivery
Shanxi Medical University
2023-2024
Shaanxi Normal University
2024
Shanxi Academy of Medical Sciences
2021-2023
Xinjiang Medical University
2021-2022
First Affiliated Hospital of Xinjiang Medical University
2021-2022
Dongguan People’s Hospital
2021
Southern Medical University
2021
TCM-Intigrated Cancer Center of Southern Medical University
2017
Wenzhou Medical University
2016
The University of Tokyo
2004-2005
Breast cancer is the most common malignancy and leading cause of death among women. TIMELESS (TIM), a circadian rhythm regulator, has been recently implicated in progression human cancer. However, role TIM breast not well-characterized. Immunohistochemistry (IHC) staining was used to examine levels specimens. Mammosphere formation analysis side population were effect on self-renewal stem cells. A wound healing assay Transwell determine cell migration invasion. soft agar growth vitro...
The minichromosome maintenance (MCM) protein complex is important for DNA replication. Moreover, the expression of specific MCM components has been associated with survival hepatocellular carcinoma (HCC) patients. However, and functional roles component 4 (MCM4) in HCC development progression have not yet explored. We analyzed clinical significance MCM4, including its association liver cancer patient survival.Oncomine, UALCAN, HCCDB (a database atlas) were used to characterize MCM4 tumor...
Introduction. Vascular smooth muscle cells (VSMCs) are highly involved in airway vascular remodeling asthma. Objectives. This study aimed to investigate the mechanisms underlying effects of a disintegrin and metalloproteinase-33 (ADAM33) gene on migration capacity inflammatory cytokine secretion VSMCs. Methods. Human aortic (HASMCs) were transfected with lentiviral vectors carrying short hairpin RNA (shRNA) targeting ADAM33 or negative control vectors. The HASMCs was evaluated by transwell...
Accumulating evidence suggests that pulmonary expression of a disintegrin and metalloproteinase‑33 (ADAM33) serves key role in the pathogenesis airway remodeling‑related diseases, including asthma. Airway vascular proliferation has been recognized as feature remodeling. Our previous study showed ADAM33 is constitutively expressed smooth muscle cells patients with asthma, suggesting potential regulating Using <em>in vitro</em> human aortic (HASMCs) lentiviral vector carrying short hairpin RNA...
To investigate the effect of loss myeloid-derived growth factor (Mydgf) on transformation cardiac fibroblasts into myofibroblasts after myocardial infarction (MI).
Gram-negative bacteria are the main bacterial pathogens infecting Chinese giant salamanders (Andrias davidianus; CGS) in captivity and wild, causing substantial economic losses CGS industry. However, molecular mechanisms underlying pathogenesis following infection remain unclear.
Background & Objectives: Acute Respiratory Distress Syndrome (ARDS) is common and frequently fatal condition characterized by overwhelming inflammation. Resolution of inflammation an active biological process regulated endogenous specialized lipid mediators including resolvins. Fibroblasts, farfrom being matrix-producing reparative cells, could exhibit specific function in resolution. Cyclooxygenase-2(COX-2) inducible inflammatory stimuli was reported to drive peaking onset as well resolve...
The decision for definitive therapy the treatment of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) is difficult. Patients CTD-ILD received 0.5 g twice a day mycophenolate mofetil 2 years (MMF cohort, n = 105) or cyclophosphamide 50 mg once every other day, and cumulative dose should not exceed 10 (CYC 140). After complete (EL), % forced vital capacity (FVC) diffusing lungs carbon monoxide were increased in both MMF CYC cohorts as compared to before (p...