A5077403974- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Occupational and environmental lung diseases
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
Yale University
2023-2025
SleepMed
2024
Changes in peripheral blood cell populations have been observed, but not detailed, at single-cell resolution idiopathic pulmonary fibrosis (IPF).
Fibrotic hypersensitivity pneumonitis (FHP) is a debilitating interstitial lung disease driven by incompletely understood immune mechanisms.
Abstract Rationale Changes in peripheral blood cell populations have been observed but not detailed at single-cell resolution idiopathic pulmonary fibrosis (IPF). Objectives To provide an atlas of the changes immune system stable and progressive IPF. Methods Peripheral mononuclear cells (PBMCs) from IPF patients controls were profiled using 10x Chromium 5’ RNA sequencing (scRNA-seq). Flow cytometry was used for validation. Protein concentrations Regulatory T-cells (Tregs) Monocytes...
Abstract Hypoxemia impairs cardiopulmonary function. We investigated pulmonary artery remodeling in mice exposed to chronic hypoxia for up five weeks and quantified associated changes cardiac lung function, without or with subsequent normoxic recovery the absence presence of exercise pharmacological intervention. Hypoxia-induced stiffening proximal stemmed primarily from adventitial collagen, which resulted part altered inter-cellular signaling phenotypic mural smooth muscle cells...
Abstract Rationale and Objectives The extent commonality of peripheral blood immune aberrations in fibrotic interstitial lung diseases are not well characterized. In this study, we aimed to identify common distinct patients with idiopathic pulmonary fibrosis (IPF) hypersensitivity pneumonitis (FHP) using cutting-edge single-cell profiling technologies. Methods Single-cell RNA sequencing was performed on healthy controls’ bronchoalveolar lavage samples 10X Genomics 5’ gene expression V(D)J...