A5092591366- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Electron Spin Resonance Studies
- Advanced NMR Techniques and Applications
- Particle Accelerators and Free-Electron Lasers
- Advanced Electrical Measurement Techniques
- Advanced Fluorescence Microscopy Techniques
- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Power Transformer Diagnostics and Insulation
- Advanced Neuroimaging Techniques and Applications
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Nuclear Physics and Applications
- Electrical and Bioimpedance Tomography
- Mass Spectrometry Techniques and Applications
- Advanced Fiber Optic Sensors
- Semiconductor Quantum Structures and Devices
- Chemical Reactions and Isotopes
Max Planck Institute for Biological Cybernetics
2023-2025
University of Tübingen
2025
We demonstrated the feasibility of using bSSFP acquisitions for off-resonance insensitive high-resolution [6,6'-2H2]-glucose deuterium metabolic imaging (DMI) studies in healthy human brain at 9.4T. Balanced SSFP have potential to improve sensitivity DMI despite SNR loss phase-cycling and other scanner constraints.We investigated two variants acquisitions, namely uniform-weighted multi echo acquisition-weighted CSI with oral labelled-glucose intake. Phase-cycling was introduced make less...
Abstract Objective Low-field magnetic resonance imaging is currently developing into a valuable diagnostic tool due to its simplicity of magnet array designs. Particularly, this allows the development scanners as part educational workshops, thus ensuring knowledge transfer and empowering local scientists design tailored solutions for specific problems. To obtain maximum performance, needs be shimmed requiring an automated system measuring spatial field distribution. Methods A self-designed...
Abstract Purpose This work aims to improve the speed of balanced SSFP (bSSFP) acquisition with segmented 3D stack‐of‐spirals for functional brain studies at ultrahigh field. Methods Functional experiments were performed an accelerated sequence water excitation fat suppression. The resulting data reconstructed using iterative algorithm corrections system imperfections such as trajectory deviations and B 0 inhomogeneity. In first set experiments, we evaluated signal change stability respect...
We explored the spatio-temporal resolution and coverage of bSSFP BOLD contrast using a highly segmented 3D spiral readout. The functional activation maps acquired with novel for full visual field checkerboard stimulus is presented at submillimeter resolutions (0.6 mm3 & 0.8 mm3) 1.2 whole brain coverage. also demonstrated rapid slice-selective water excitation binomial pulses.
Motivation: Gradient imperfections and significant field fluctuations due to physiology at higher can degrade the image quality thus limit use of certain readout trajectories. Goal(s): To perform concurrent monitoring encoding gradients other spatio-temporal variations during imaging 9.4 Tesla. Approach: We optimized, designed manufactured a highly customizable field-probe insert for 16Tx/32Rx RF array performed an initial in-vivo experiment. Results: The locations probes yield good...
Motivation: Efficient, distortion-free, and selective to microvessels: these attributes make bSSFP an attractive candidate for fMRI. 2D multi-slice scans in the transient state are increasingly employed as alternative 3D steady-state imaging improve localization. Goal(s): To evaluate BOLD sensitivity of during phase compared steady state. Approach: acquisitions utilized task-based Monte Carlo simulations vitro microsphere experiments conducted verify vivo results. Results: An inversion...
Motivation: Deuterium metabolic imaging could significantly impact the field of neuro-oncology by providing clinical quantitative information. Goal(s): To improve spatial resolution human deuterium at 9.4 T. Approach: We performed phantom and in vivo experiments with oral intake deuterated glucose using multi-echo phase-cycled bSSFP acquisitions. The results were compared a standard 3D spectroscopy sequence. Results: achieved higher to Phase cycling improved reliability metabolite...
We investigate the possibility of using longer multi-shot spiral readouts to accelerate balanced steady-state free precession (bSSFP) at ultra-high field (UHF) for functional imaging. The reconstruction is performed with full signal model accounting spatial B 0 inhomogeneity and gradient imperfections. present activation maps from flickering checkerboard stimulus experiment discuss challenges bSSFP UHF.