A5022824697- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Mesenchymal stem cell research
- TGF-β signaling in diseases
- Extracellular vesicles in disease
Chinese Academy of Agricultural Sciences
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
Radboud University Medical Center
2023
Radboud University Nijmegen
2023
Abnormal osteoclast and osteoblast differentiation is an essential pathological process in osteoporosis. As important deubiquitinase enzyme, ubiquitin-specific peptidase 7 (USP7) participates various disease processes through posttranslational modification. However, the mechanism by which USP7 regulates osteoporosis remains unknown. Herein, we aimed to investigate whether abnormal osteoporosis.The gene expression profiles of blood monocytes were preprocessed analyze differential USP genes....
Mesenchymal stromal/stem cell derived-extracellular vesicles (MSC-EVs) have gained interest as drug delivery nanoparticles, having immunoregulatory and potentiating tissue repair property. To maintain growth of MSCs obtain pure MSC-derived EVs, the culture media should contain fetal bovine serum (FBS) devoid presence FBS EVs confounds properties MSC-EVs. Therefore, we tested three methods: 18h ultracentrifugation (UC) ultrafiltration (UF), which are common EV depletion methods in current...