A5049837051- Diamond and Carbon-based Materials Research
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Electronic and Structural Properties of Oxides
- Protein Kinase Regulation and GTPase Signaling
- Advanced Surface Polishing Techniques
- Biochemical and Structural Characterization
- Career Development and Diversity
- Educational Strategies and Epistemologies
- Innovative Teaching Methods
- Mentoring and Academic Development
- Education, Achievement, and Giftedness
- Service-Learning and Community Engagement
- Force Microscopy Techniques and Applications
- Advanced materials and composites
- Carbon Nanotubes in Composites
- Graphene research and applications
San Jose State University
2022-2023
University of California, San Francisco
2023
University of Chicago
2021
Protein S-acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, installation onto proteins catalyzed by family 23 Asp-His-His-Cys domain-containing protein acyltransferases (DHHC-PATs). DHHCs are increasingly recognized as critical players in cellular signaling events human disease. However, progress elucidating functions mechanisms DHHC "writers" has been hampered lack chemical tools to perturb their live...
Course-based undergraduate research experiences (CURE) enhance student retention in science, technology, engineering, and math (STEM), particularly among students who belong to historically excluded communities. Yet the mechanisms by which CUREs contribute integration persistence are poorly understood. Utilizing tripartite model of social influence (TIMSI), this longitudinal study examines whether how Tiny Earth-an antibiotic-discovery CURE designed for flexible implementation a variety...
Surface chemistry of materials that host quantum bits such as diamond is an important avenue exploration computation and sensing platforms mature. Interfacing in general nanoscale (ND) particular with silica a potential route to integrate room temperature into photonic devices, fiber optics, cells, or tissues flexible functionalization chemistry. While growth on ND cores has been used successfully for biolabeling, the surface mechanism initiate was unknown. This report describes responsible...
Bromination of high-pressure, high-temperature (HPHT) nanodiamond (ND) surfaces has not been explored and can open new avenues for increased chemical reactivity diamond lattice covalent bond formation. The large dissociation energy the lattice–oxygen is a challenge that prevents bonds from forming, most researchers simply use oxygen-terminated NDs (alcohols acids) as reactive species. In this work, we transformed tertiary-alcohol-rich ND surface to an amine with ∼50% coverage was limited by...
Introduction Despite numerous (co)curricular efforts, diversifying the Science, Technology, Engineering, and Mathematics (STEM) research workforce remains challenging large segments of U.S. population continue to be underrepresented. Promoting instructor–student mentoring relationship quality is a potentially important mechanism support biomedical diversity, as has been positively associated with learning persistence. We tested impact “Creating Birds Feather” (CBoaF) intervention designed...
ABSTRACT Course-based undergraduate research experiences (CUREs) enhance student retention in STEM, particularly among students who belong to historically excluded communities. Yet the mechanisms by which CUREs contribute integration and persistence are poorly understood. Utilizing Tripartite Integration Model of Social Influence (TIMSI), this longitudinal study examines how Tiny Earth, an antibiotic-discovery CURE, impacts students’ scientific self-efficacy, identity, endorsement community...
Surface chemistry of materials that host quantum bits such as diamond are an important avenue exploration computation and sensing platforms mature. Interfacing in general, nanoscale (ND) particular with silica is a potential route to integrate the bit into photonic device, fiber optic, cells or tissues flexible functionalization chemistry. While growth on ND cores has been used successfully for biolabeling, surface mechanism initiate was unknown. This report describes responsible bond...
<p>Protein <i>S</i>-acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, installation onto proteins catalyzed by family 23 Asp-His-His-Cys domain-containing protein acyltransferases (DHHC-PATs). DHHCs are increasingly recognized as critical players in cellular signaling events human disease. However, progress elucidating functions mechanisms DHHC “writers” has been hampered lack chemical...
Surface chemistry of materials that host quantum bits such as diamond are an important avenue exploration computation and sensing platforms mature. Interfacing in general, nanoscale (ND) particular with silica is a potential route to integrate the bit into photonic device, fiber optic, cells or tissues flexible functionalization chemistry. While growth on ND cores has been used successfully for biolabeling, surface mechanism initiate was unknown. This report describes responsible bond...
Bromination of high-pressure high-temperature (HPHT) nanodiamond (ND) surfaces has not been explored and can open new avenues for increased chemical reactivity diamond lattice covalent bond formation. The large dissociation energy the lattice-oxygen is a challenge that prevents bonds from forming most researchers simply use oxygen-terminated ND (alcohols acids) as reactive species. In this work, we transformed tertiary alcohol-rich surface to an amine with 50% coverage was limited by...
<p>Protein <i>S</i>-acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, installation onto proteins catalyzed by family 23 Asp-His-His-Cys domain-containing protein acyltransferases (DHHC-PATs). DHHCs are increasingly recognized as critical players in cellular signaling events human disease. However, progress elucidating functions mechanisms DHHC “writers” has been hampered lack chemical...
Protein S -acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, installation onto proteins catalyzed by family 23 Asp-His-His-Cys domain-containing protein acyltransferases (DHHC-PATs). DHHCs are increasingly recognized as critical players in cellular signaling events human disease. However, progress elucidating functions mechanisms DHHC “writers” has been hampered lack chemical tools to perturb their live...
Protein S -acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, installation onto proteins catalyzed by family 23 Asp-His-His-Cys domain-containing protein acyltransferases (DHHC-PATs). DHHCs are increasingly recognized as critical players in cellular signaling events human disease. However, progress elucidating functions mechanisms DHHC “writers” has been hampered lack chemical tools to perturb their live...