A5063683519- Tendon Structure and Treatment
- Genomics and Rare Diseases
- Shoulder Injury and Treatment
- Pregnancy-related medical research
- Genetic Associations and Epidemiology
- Exercise and Physiological Responses
- Sports injuries and prevention
- Endometriosis Research and Treatment
- Connective tissue disorders research
- Lower Extremity Biomechanics and Pathologies
- Wound Healing and Treatments
- Osteoarthritis Treatment and Mechanisms
- Genomics and Phylogenetic Studies
- Tissue Engineering and Regenerative Medicine
- Veterinary Equine Medical Research
- Molecular Biology Techniques and Applications
- Immune Response and Inflammation
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Dermatologic Treatments and Research
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Inflammatory mediators and NSAID effects
University of Toronto
2023-2024
University of Calgary
1997-2015
Alberta Bone and Joint Health Institute
2010-2013
It was hypothesized that mobilization vs immobilization after injury would promote tissue healing by regulating gene expression for molecules associated with repair. Cast free studied rat Achilles tendon rupture. Reverse transcriptase‐polymerase chain reaction performed at 8 and 17 days post‐rupture to assess different growth factors [brain‐derived neurotrophic factor (BDNF), basic fibroblast (bFGF), nerve (NGF) insulin‐like factor‐1 (IGF‐1)] inflammatory mediators [cyclooxygenase 1 2 (COX...
Abstract The purpose of the study was to contribute mapping molecular events during flexor tendon healing, in particular growth factors insulin‐like factor‐1 (IGF‐1), vascular endothelial factor (VEGF) and nerve (NGF), matrix metalloproteinases (MMP‐3 MMP‐13) their inhibitors (tissue metalloproteinases, TIMP‐1 TIMP‐3, protease cathepsin K. In a rabbit model injury, mRNA expression for factors, MMPs TIMPs were measured sheath tissue at several time points (3, 6, 21, 42 days) representing...
Widespread sequencing has yielded thousands of missense variants predicted or confirmed as disease-causing. This creates a new bottleneck: determining the functional impact each variant - largely painstaking, customized process undertaken one few genes at time. Here, we established high-throughput imaging platform to assay coding variation on protein localization, evaluating 3,547 over 1,000 and phenotypes. We discovered that mislocalization is common consequence variation, affecting about...
Objectives Ligaments which heal spontaneously have a healing process that is similar to skin wound healing. Menopause impairs and may likewise impair ligament Our purpose in this study was investigate the effect of surgical menopause on rabbit medial collateral model. Methods Surgical induced with ovariohysterectomy surgery adult female rabbits. Ligament injury created by making gap midsubstance ligament. were allowed for six or 14 weeks presence absence oestrogen before being compared...
Introduction The incidence of tendinopathy increases with aging. Alterations to the balance between matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) may play a role in degenerative changes seen tendinopathy.1 In addition, aging have an effect on expression these molecules tendon, as was found skin.2 Our purpose this study examine patellar tendons from 1-year-old 3-year-old rabbits comparing molecular MMPs TIMPs. hypothesis that would increased MMP decreased TIMP compared...
Background Cyclooxygenases (COXs) modulate prostaglandin synthesis in the gastrointestinal tract. Prostaglandins have been shown to a cytoprotective effect on bowel mucosa adults, but no similar data are available neonates. Thus, purpose of current study was evaluate age-dependent changes tract COX regulation after Escherichia coli lipopolysaccharide exposure rats. Methods Stomach, small bowel, and large COX-1 COX-2 mRNA levels (reverse transcription polymerase chain reaction technique)...