A5052511797- Clinical Nutrition and Gastroenterology
- Biochemical Analysis and Sensing Techniques
- Genetic Mapping and Diversity in Plants and Animals
- Regulation of Appetite and Obesity
- Rice Cultivation and Yield Improvement
- Immune Response and Inflammation
- Wound Healing and Treatments
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Hormonal and reproductive studies
- Urinary Bladder and Prostate Research
- Inflammatory Bowel Disease
- Antimicrobial Peptides and Activities
- Immunodeficiency and Autoimmune Disorders
- Plant nutrient uptake and metabolism
- Dermatologic Treatments and Research
- Protease and Inhibitor Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Cervical Cancer and HPV Research
- Prostate Cancer Diagnosis and Treatment
- Characterization and Applications of Magnetic Nanoparticles
- Galectins and Cancer Biology
- Antimicrobial agents and applications
- Ocular Surface and Contact Lens
China National Rice Research Institute
2023-2024
Luxun Academy of Fine Arts
2024
University of Michigan
2003-2022
Michigan Medicine
2020
Fourth Affiliated Hospital of Guangxi Medical University
2016-2019
Guangxi Medical University
2010
Jiaxing Vocational Technical College
2008
C. S. Mott Children's Hospital
2002-2003
A. Alfred Taubman Health Care Center
2003
Ghrelin, a gastric peptide hormone, has been reported to regulate growth hormone secretion and energy homeostasis. Here we show that ghrelin promotes neural proliferation in vivo vitro the rat dorsal motor nucleus of vagus (DMNV). Ghrelin receptor mRNA immunoreactivity were detected tissues from DMNV. Systemic administration (130 nmol kg −1 ) significantly increased 5‐bromo‐2′‐deoxyuridine (BrdU) incorporation DMNV adult rats with cervical vagotomy (BrdU positive cells; 27 ± 4 69 14 n = 5, P...
Ghrelin, a novel gastric hormone, regulates food intake and energy metabolism via central mechanisms. The peripheral effect of ghrelin on adiposity is poorly understood. We established stable 3T3-L1 cell line expressing to study the direct adipogenesis. Cells overexpressing demonstrate significantly attenuated differentiation preadipocytes into adipocytes. Expression peroxisome proliferator-activator receptor-gamma inhibited as demonstrated by decrease mRNA protein. Both overexpression...
The development of effective intranasal vaccines is great interest due to their potential induce both mucosal and systemic immunity. Here we produced oil-in-water nanoemulsion (NE) formulations containing various cationic nonionic surfactants for use as adjuvants the delivery vaccine antigens. NE induced immunogenicity antigen are believed be facilitated through initial contact interactions between droplet surfaces which promote prolonged residence at site application, thus cellular uptake....
Objective To determine the etiology of loss epithelial barrier function observed with administration total parenteral nutrition (TPN) in a mouse model. Summary Background Data Removal enteral TPN is associated intestinal function. The this not clear. Because intraepithelial lymphocytes (IELs) produce number cytokines that may alter permeability, authors investigated IEL cytokine expression model TPN. Methods Adult C57BL/6 mice received or diet for 7 days. IELs were subsequently harvested and...
Total parenteral nutrition (TPN) results in an increase intraepithelial lymphocyte (IEL)-derived interferon-γ (IFN-γ) expression as well epithelial cell (EC) apoptosis. This study examined the role that IEL-derived IFN-γ has EC Mice received either TPN or oral feedings for 7 days. Small bowel apoptosis significantly rose mice receiving TPN. The administration of also increased and Fas ligand (FasL) expression. knockout (IFNKO) was lower than wild-type mice. Sensitivity to Fas-mediated IFNKO...
There have been several reports that TNF-related apoptosis-inducing ligand (TRAIL) has the ability to suppress development of experimental autoimmune diseases, including a mouse model encephalomyelitis, rabbit rheumatoid arthritis, type 1 diabetes mellitus, in mice and thyroiditis (EAT) mice. However, mechanism underlying TRAIL effect is not well defined. In present study, we specifically examined effects on CD4+CD25+ regulatory T cells. cells prepared from thyroglobulin (mTg)-immunized...
To develop NB-201, a nanoemulsion compound, as novel microbicidal agent against methicillin-resistant Staphylococcus aureus (MRSA) infection, which is common threat to public health but with limited therapeutic options.NB-201 was tested in vitro and vivo murine porcine models infected MRSA.Topical treatment of MRSA-infected wounds NB-201 significantly decreased bacterial load had no toxic effects on healthy skin tissues. attenuated neutrophil sequestration inhibited epidermal deep dermal...
Abstract Three key factors determine yield in rice (Oryza sativa): panicle number, grain and weight. Panicle number is strongly associated with tiller number. Although many genes regulating tillering have been identified, whether Dof proteins are involved controlling plant architecture remains unknown. The dwarf less tillers on chromosome 3 (dlt3) mutant produces fewer than the wild type. We cloned DLT3, which encodes a protein that interacts MONOCULM (MOC3) vivo vitro recruits MOC1, forming...
Vaccination is the most effective approach to prevent infection with highly pathogenic avian influenza (HPAI). Adjuvants are often used induce immune responses and overcome immunological weakness of recombinant HPAI antigens. Given logistical challenges immunization during pandemic situations, vaccines administered via intramuscular (I.M.) route would be value.A new formulation nanoemulsion adjuvant (NE02) suitable for I.M. vaccination was developed. This NE02 evaluated alone in combination...
The aim of this study was to investigate the impact a novel nanoemulsion (NE) adjuvant, soybean oil emulsion, on autoimmune response. To end, we used murine thyroglobulin (mTg)-induced experimental thyroiditis in mice as model.Mice received NE or + mTg by nasal delivery. At 1 week after second delivery with without mTg, all were immunized and lipopolysaccharides induce thyroiditis.Compared controls, mTg-NE-treated had much more antigens accumulated passage thymus developed milder form...
HER2 is an oncogenic tumor-associated antigen overexpressed in 20-25% of breast cancers, which associated with increased invasion, metastasis the disease and resistance to therapy.Recent studies have further shown that can increase population cancer stem cells (BCSCs).However, there currently no vivo model for study + BCSCs.In this study, we characterized a mouse BCSCs.This was accomplished by inoculating mammary tumor EO771 engineered human wild-type (EO771E2) into C57BL/6 transgenic mice...
Despite advances in antimicrobial therapies, wound infection remains a global public health concern. We aimed to formulate and assess various nanoemulsions (NEs) for potential effectiveness as stable agents suitable topic application. A total of 106 NEs were developed that varied with respect nonionic cationic surfactants. Stability testing demonstrated the tested are broadly stable, 97/106 formulations passing 2-week stability tests. Two NEs, NB-201 NB-402, selected test activity model...
A nanoemulsion (NE) is a surfactant-based, oil-in-water, nanoscale, high-energy emulsion with mean droplet diameter of 400-600 nm. When mixed antigen and applied nasally, NE acts as mucosal adjuvant induces immune responses. One possible mechanism for the effect this material that it augments uptake distribution to lymphoid tissues, where response generated. Biocompatible iron oxide nanoparticles have been used unique imaging approach study dynamics cells or molecular migration. To NEs track...
Wound infections with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) are particularly difficult to treat present a great challenge clinicians. Nanoemulsions (NE) novel oil-in-water emulsions formulated from soybean oil, water, solvent, surfactants such as benzalkonium chloride (BZK). An optimal ratio of those components produces nanometer-sized particles the positive-charged surfactant at their oil-water interface. We sought investigate...
This research focuses on 72 approved varieties of colored wheat from different provinces in China. Utilizing coefficients variation, structural equation models, and correlation analyses, six agronomic traits were comprehensively evaluated, followed by further dwarfing genes wheat. Using the entropy method revealed that among varieties, 10 suitable for cultivation. Variety 70 was top-performing variety, with a comprehensive index 87.15%. In final established model, each trait exhibited...
BID functions as a bridge molecule between death-receptor and mitochondrial related apoptotic pathways to amplify signaling. Our previous studies have demonstrated substantial increase in expression primary normal thyroid epithelia cells treated with inflammatory cytokines, including the combination of IFNγ IL-1β or TNFα. The aim this study was determine whether an can induce autoimmune thyroiditis.A transgenic mouse line that expresses human established by fusing thyroglobulin (Tg) promoter...
Tiller number (TN) is an important trait that contributes to yield in rice (Oryza sativa L.). A set of 76 chromosome segment substitution lines (CSSLs) derived from the super-hybrid cross between Zhonghui 9308 (ZH9308) and Xieqingzao B (XQZB) was used map quantitative loci (QTL) controlling tiller (TN). total four QTLs were detected Fuyang, Zhejiang Province (30.15° N, 120° E). Two Lingshui, Hainan (18.5° 110° E) our previous study. To further QTL on 4, namely qTN4, line CSSL29 with a lower...
The aim of this study was to assess changes in sexual function after 980-nm diode laser vaporization the prostate.A total 82 benign prostatic hyperplasia (BPH) patients underwent from May 2013 December 2016, and were followed up for 12 months. following outcomes assessed at baseline, 6, months postoperatively: international prostate symptom score (IPSS), quality life (QoL) score, maximum urinary flow rate (Qmax), five-item version index erectile dysfunction questionnaire (IIEF-5), male...