A5038732643- Renal Diseases and Glomerulopathies
- Lignin and Wood Chemistry
- Advanced Surface Polishing Techniques
- Polymer composites and self-healing
- Vasculitis and related conditions
- Advanced Machining and Optimization Techniques
- Complement system in diseases
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
- Natural Fiber Reinforced Composites
- Advanced machining processes and optimization
- Systemic Lupus Erythematosus Research
- Renal Transplantation Outcomes and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Digital Marketing and Social Media
- Art History and Market Analysis
- Dielectric materials and actuators
- Astronomical Observations and Instrumentation
- Nanowire Synthesis and Applications
- Advancements in Battery Materials
- Astronomy and Astrophysical Research
- Supercapacitor Materials and Fabrication
- Stellar, planetary, and galactic studies
- Polymer Nanocomposites and Properties
Peking University
2016-2025
Peking University First Hospital
2016-2025
Jiangsu University
2023-2025
Shandong First Medical University
2025
Nanjing University of Aeronautics and Astronautics
2023-2024
Institute of New Materials
2023-2024
Yanshan University
2024
Anhui Xinhua University
2024
King University
2022-2023
Materials Science & Engineering
2023
Epitopes of phospholipase A2 receptor (PLA2R), the target antigen in idiopathic membranous nephropathy (iMN), must be presented by HLA–encoded MHC class II molecules to stimulate autoantibody production. A genome–wide association study identified risk alleles at HLA and PLA2R loci, with top variant rs2187668 within HLA-DQA1 showing a effect greater than that rs4664308 PLA2R1. How affect epitope presentation iMN is unknown. Here, we genotyped 261 patients 599 healthy controls HLA-DRB1,...
Thrombospondin type-I domain-containing 7A (THSD7A) was recently identified as the target antigen in about 10% of patients with M-type phospholipase A2 receptor (PLA2R)-negative membranous nephropathy European and North American populations. The prevalence THSD7A other populations their clinical associations deserve further clarification.Immunofluorescence assay performed to investigate anti-THSD7A antibodies 578 consecutive biopsy-proven idiopathic nephropathy, 114 secondary 64 disease...
Complement activation plays a substantial role in the pathogenesis of primary membranous nephropathy (pMN). C5b-9, C3c, MBL, and factor B have been documented subepithelial immune deposits. However, changing complement products circulation urine is not clear. We measured circulating urinary levels C1q, C4d, Bb, properdin, C3a, C5a, sC5b-9, 134 patients with biopsy-proven pMN, by enzyme-linked immunosorbent assay. All plasma values were corrected eGFR all creatinine protein excretion....
Abstract Replacing inorganic anodes with organic electrode materials is an attractive direction for future green Li‐ion batteries (LIBs). Carbonyl compounds are being explored as leading anode candidates LIBs. In particular, cyclohexanehexanone (C 6 O ), a perfect structure composed entirely of six CO groups, can theoretically contribute to the most reactive sites and highest specific capacity, but has not been used material so far owing its high solubility in carbonate‐based electrolytes...
Glomerular IgM deposition is commonly shown in primary FSGS and sometimes accompanied by C3 deposition. Clinical presentation treatment outcomes of these patients are not investigated detail.One hundred six consecutive with biopsy-proven from 2004 to 2014 were enrolled retrospectively. features compared between without IgM/C3 deposition.Fifty-eight (54.7%) presented glomerular on sclerotic segments. C1q depositions exclusively (34.5% versus 0.0%; P<0.001 8.6% P=0.04, respectively). Patients...
Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease. Recent studies have proposed that plasma soluble urokinase receptor (suPAR) might be causative circulating factor but this proposal has caused controversy. This study aimed to measure urinary suPAR levels in patients with primary FSGS and its significance the pathogenesis FSGS. Sixty-two FSGS, diagnosed between January 2006 2012, complete clinical pathologic data were enrolled, together disease normal...
The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, elevation of anti-PLA2R antibodies, no remission, and so on. It was controversial whether the histopathological features pMN could predict treatment response outcome. A retrospective study conducted 371 patients with biopsy-proven pMN. Pathological parameters included immunofluorescence...
Background Studies on adriamycin mice model suggest complement system is activated and together with IgM contributes to the glomerular injury of primary focal segmental glomerulosclerosis (FSGS). We recently reported FSGS patients C3 deposition showed unfavorable therapeutic responses worse renal outcomes. Here we examined plasma urinary profile FSGS, aiming investigate participation in pathogenesis. Methods Seventy biopsy-proven were enrolled. The levels C3a, C5a, soluble C5b-9, C4d, C1q,...
The preparation of biological phenolic resin (PF) with green recyclable biomaterials instead phenol is a research hotspot for solving current resource and environmental problems. In this study, on the basis introducing lignin into system, daidzein renewable rigid structure was selected to modify lignin-based (LPF), improvement mechanical thermal properties modified under different substitution ratios studied. friction materials were prepared daidzein-modified (D-LPF) as matrix binder, their...
Relapse of membranous nephropathy (MN) and other glomerular diseases has been observed after COVID-19 infection. The risk factors contributing to disease progression in MN patients contracting remain unclear. This retrospective study included 656 consecutive with biopsy-proven primary who received treatment were regularly followed up for over six months. Logistic regression analyses conducted identify progression. Among the cohort, 555 (84.6%) contracted from November 11th, 2022, February...
Purpose Embryo engineering requires a large number of oocytes, which undergo in vitro maturation (IVM). Understanding how to select the best quality oocytes is key improving IVM efficiency. Oocytes have different germinal vesicle (GV) chromatin configurations, may explain heterogeneity oocyte during IVM. However, no reports categorized, configuration rat GVs or evaluated, association between and development. Methods The GV was divided into seven types according degree compaction:...
Abstract Replacing petroleum‐based raw materials with renewable is now obviously more in line the needs of sustainable development. In this work, lignin, tung oil and linseed were selected to prepare modified lignin based phenolic resin (T‐LPF) (L‐LPF). T‐LPF L‐LPF characterized by FTIR, DSC, DMA, TGA, universal testing machine, SEM, friction wear tester 3D profilometer. The results show that compared PF LPF, introduction can reduce curing activity increase peak temperature. have better...
Although complement activation is believed to be important in mediating PMN, the pathways involved and clinical consequences remain controversial. Many cases of idiopathic or primary membranous nephropathy (PMN) present with subepithelial C1q deposits along IgG C3 on glomerular capillary walls but without IgA IgM ("full house") by immunofluorescence any causes secondary MN. We sought define pathological significance these PMN comparing a variety parameters, outcomes other serum urine factors...
Abstract It is of interest to develop wide-temperature domain damped hydrophobic materials. In this paper, we designed incorporating bio-based phenolic resin into the IIR matrix and introducing dibenzyl fork acetone (DBA) main chain structure with sodium hydroxide activation construct three-dimensional network. The added has reticulated blended butyl rubber, combined hydride activation-modified IIR. results show that activated modification DBA introduced by infrared 1 H NMR analysis....
Abstract Background The objective of this research was to examine the impact monocyte-to-lymphocyte ratio (MLR) on advancement hematoma after cerebral contusion. Methods clinical information and laboratory test findings people with contusion were retrospectively analyzed. Using tertiles MLR, study participants categorized into three groups, enabling evaluation correlation between MLR Results Among cohort patients showing progression, levels significantly higher compared nonprogress group ( P...
The preparation of green bio-based phenolic resin with high performance has far-reaching significance for sustainable development and is an important research direction researchers in recent years. In this study, a novel resveratrol-modified lignin-based (R-LPF) ultra-high Tg improved mechanical properties was synthesized biomass phenol resveratrol lignin as raw materials. curing behaviors (PF), (LPF) R-LPF were investigated. thermal properties, stability, comprehensive frictional morphology...
Background: To observe effectiveness and renal safety of long-term low-dose cyclosporine in idiopathic membranous nephropathy (IMN).Methods: Sixty-eight patients were enrolled this prospective cohort study. Renal endpoint was defined as a decrease eGFR ≥50% from baseline development ≤60 ml/min/1.73m2.Results: A dose 2.0 ± 0.5 mg/kg/d prednisone 0.3 0.2 prescribed. The duration treatment 27 (3–80) months. overall remission rate 91% with relapse 42%. Fourteen had cyclosporine-related acute...
Focal segmental glomerulosclerosis (FSGS) is an important cause of refractory nephrotic syndrome (NS) in children and adults. Urinary CD80 elevated some patients with primary FSGS, however, its clinical value not fully clarified. This study aims to evaluate the pathological significance urinary FSGS.Sixty-one adult biopsy-proven standard treatment long-term follow up, were enrolled retrospectively. CD80, on day kidney biopsy, was measured using commercial ELISA kits adjusted by creatinine...