A5102739381- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Aortic aneurysm repair treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Aortic Disease and Treatment Approaches
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Infectious Aortic and Vascular Conditions
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Radiotherapy Techniques
- Cardiac Imaging and Diagnostics
- Cellular Mechanics and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Structural Anomalies and Repair
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
Fudan University
2016-2025
Zhongshan Hospital
2016-2025
University of South China
2020-2025
Sun Yat-sen University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Shanghai Institute of Hematology
2015-2023
Chenzhou First People's Hospital
2010-2023
Nanyang Technological University
2016-2019
National University Health System
2018
Minnesota Project
2017
Inflammation and calcification concomitantly drive atherosclerotic plaque progression rupture are the compelling targets for identifying vulnerability. However, current imaging modalities vulnerable plaques often limited by inadequate specificity sensitivity. Here, we show that natural H-ferritin nanocages radiolabeled with technetium-99m (99mTc-HFn) can identify accurately localize macrophage-rich, in living mice using combined SPECT CT. Focal 99mTc-HFn uptake was observed multiple...
Purpose Although intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma, there are limited data available on PET/CT imaging in ICC. This retrospective study analyzed role of evaluation Methods FDG findings were reviewed 65 patients with histologically confirmed was evaluated based visual interpretation and semiquantitative index SUVmax tumor-to-normal liver tissue ratio (TNR), which consequently further correlated tumor...
The present study aimed to evaluate the feasibility of ultra-low <sup>18</sup>F-fluorodeoxyglucose (FDG) activity in total-body positron emission tomography (PET)/computed (CT) oncological studies. <b>Methods:</b> Thirty patients with cancer were enrolled prospectively and underwent a PET/CT examination an <sup>18</sup>F-FDG (0.37 MBq/kg) after uptake time 60 minutes. Among patients, 11 diagnosed colorectal (CRC). PET raw data acquired within 15 minutes reconstructed using from first 1, 2,...
The present study aimed to explore the boundary of acquisition time and propose an optimized range for total-body positron emission tomography (PET)/computed (CT) oncological imaging using half-dose (1.85 MBq/kg) 18F-fluorodeoxyglucose activity based on diagnostic needs.In this retrospective a PET system (uEXPLORER), exploration cohort (October 2019-December 2019) 46 oncology patients was first studied. all 15 min, acquired images were reconstructed further split into 15-, 8-, 5-, 3-, 2-,...
Abstract Purpose The purpose of this study was to investigate the image quality and diagnostic performance different reconstructions over a wide range patient body mass indices (BMIs) obtained by total-body PET/CT with ultra-low 18 F-FDG activity (0.37 MBq/kg). Methods A total 63 patients who underwent MBq/kg) were enrolled. Patients grouped their BMIs. Images reconstructed following two algorithms: ordered subset expectation maximization (OSEM) algorithm (2, 3 iterations), both time flight...
Abstract Traditional imaging modalities used to monitor the diameter of aortic aneurysms (AAs) often fail follow pathological progression. Fibroblast activation protein (FAP), a key regulator extracellular matrix (ECM) remodeling, plays pivotal role in disease. However, its expression wall during aneurysm progression and potential correlation with disease severity remains unexplored. Here, utilizing histology levels FAP are higher patients AA compared healthy controls. In three distinct...
Abstract: MCM2 belongs to the microchromosome maintenance [MCM] family and plays an essential role in initiating DNA replication as well maintaining normal cellular cycle functions. Recent research indicates that there is abnormal expression of various cancers, such breast, cervical, ovarian, lung, hepatocellular carcinoma, nephroblastoma, prostate, pancreatic where it shows a strong link tumorigenesis, growth, invasion, migration, adverse prognosis. Thus, could serve significant biomarker...
To investigate the performance of combined 18F-FDG Positron Emission Tomography/Computed Tomography with high-resolution CT for differentiating invasive adenocarcinoma from in situ (pre-invasive lesion) or minimally stage IA lung cancer patients solitary ground-glass opacity nodules. This retrospective study enrolled 58 consecutive pulmonary The characteristics and measurements nodules as pure mixed pre-invasive groups on were compared analyzed. Ground-glass group preferentially manifested...
GRB2 is an adaptor protein which interacts with phosphorylated TGF-β receptor and critical for mammary tumour growth. We found that TGF-β1-induced EMT increased expression in A549 cells (non-small cell lung cancer). Overexpression of (A549GRB2) enhanced invasion while knocking down (A549GRB2KD) reduced migration invasion, probably due to vinculin Paxillin patches A549GRB2KD cell. was more pronounced A549GRB2 attenuated cells. This could be the E-cadherin cells, even before TGF-β1...
Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously and regulates actin cytoskeleton remodeling. In order to characterize the role of N-WASP in epidermal homeostasis cutaneous biology, we generated conditional knockout mouse using CK14-cre (cytokeratin 14) ablate expression keratinocytes. N-WASPK14KO (N-WASP fl/fl ; CK14-Cre) mice were born following Mendelian genetics suggesting that keratinocytes not essential during embryogenesis. exhibited stunted growth, alopecia,...