A5055501079- Advanced Radiotherapy Techniques
- Hedgehog Signaling Pathway Studies
- Advanced Aircraft Design and Technologies
- Combustion and flame dynamics
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Radiation Therapy and Dosimetry
- Advanced Combustion Engine Technologies
- Vehicle emissions and performance
- Effects of Radiation Exposure
- Glaucoma and retinal disorders
- Radiation Dose and Imaging
- Angiogenesis and VEGF in Cancer
- Retinal Diseases and Treatments
- Catalytic Processes in Materials Science
- Radiative Heat Transfer Studies
- Zebrafish Biomedical Research Applications
- Retinal Imaging and Analysis
- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Advances in Oncology and Radiotherapy
- Hippo pathway signaling and YAP/TAZ
- Brain Metastases and Treatment
- Photoreceptor and optogenetics research
- Rangeland and Wildlife Management
Novartis (United States)
2016-2025
Novartis (China)
2024
Foundation for Biomedical Research
2020
Wabash College
2018
Molecular Oncology (United States)
2014
Kaiser Permanente South San Francisco Medical Center
2014
University of California, San Francisco
2006-2013
Medical University of Vienna
2011
University of Sheffield
2004
University of Reading
2003
A central question in Hedgehog (Hh) signaling is how evolutionarily conserved components of the pathway might use primary cilium mammals but not fly. We focus on Suppressor fused (Sufu), a major Hh regulator mammals, and reveal that Sufu controls protein levels full-length Gli transcription factors, thus affecting production activators repressors essential for graded responses. Surprisingly, despite ciliary localization most components, regulation by cilium-independent. propose...
Truncating mutations in Gli3, an intracellular effector the SHH-SMO-GLI signaling pathway, cause renal aplasia/dysplasia humans and mice. Yet, pathogenic mechanisms are undefined. Here, we report effect of decreased SHH-SMO on morphogenesis, expression SHH target genes GLI binding to Shh genes. Shhdeficiency or cyclopamine-mediated SMO inhibition disrupted organogenesis, GLI1 GLI2 proteins, but increased GLI3 repressor relative activator. kidney patterning (Pax2 Sall1) cell cycle regulators...
Plans exist to restore the fire-dependent pine (Pinus spp.)-grassland community in Ouachita National Forest and potentially throughout southeastern United States benefit endangered red-cockaded woodpecker (Picoides borealis). Restoration management techniques include wildlife stand improvement (WSI; thinning of midstory codominant trees) prescribed fire. We evaluated how habitat for affected other breeding bird species. compared avian species frequency occurrence abundance during 2 seasons...
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member G-protein coupled receptor superfamily. In mammals, Smo translocates to primary cilium upon binding Hh ligands their receptor, Patched (Ptch1), but it is unclear if ciliary trafficking sufficient for pathway activation. Here, we demonstrate that cyclopamine and jervine, two structurally related inhibitors Smo, force translocation Smo. Treatment with SANT-1, an unrelated antagonist, abrogates...
The ability of blood vessels to sense and respond stimuli such as fluid flow, shear stress, trafficking immune cells is critical the proper function vascular system. Endothelial constantly remodel their cell-cell junctions underlying cytoskeletal network in response these exogenous signals. This remodeling, which depends on regulation linkage between actin integral junction proteins, controlled by a complex signaling consisting small G proteins various downstream effectors. In this...
The rapid industrial development in the United States has not been met by an adequate attempt to prevent resultant increase traumatic deafness noisier branches of industry. This is due largely employers' refusing recognize entity for fear raising question compensation, employees' evading subject lest employment be refused those whom hearing impairment appears and a general lack interest from both legislative scientific points view. That compensation boards are making awards losses was...
Neurodegeneration in glaucoma patients is clinically identified through longitudinal assessment of structure–function changes, including intraocular pressure, cup-to-disc ratios from fundus images, and optical coherence tomography imaging the retinal nerve fiber layer. Use human post-mortem ocular tissue for basic research rising field, yet there are challenges assessing disease stage severity, since donations with informed consent often unaccompanied by detailed pre-mortem clinical...
The particles emitted from an aircraft engine combustor were investigated in the European project PartEmis. Measured aerosol properties mass and number concentration, size distribution, mixing state, thermal stability of internally mixed particles, hygroscopicity, cloud condensation nuclei (CCN) activation potential. operation conditions corresponded to modern older gas path temperatures at cruise altitude, with fuel sulphur contents (FSC) 50, 410, 1270 μg g −1 . Operation FSC showed only a...
Background: Motile cilia on the inner lining of oviductal epithelium play a central role in ovum transport toward uterus and subsequent fertilization by sperm. While basic ultrastructure 9+2 motile (nine peripheral microtubule doublets surrounding pair) has been characterized, many important steps ciliogenesis remain poorly understood. Results: Our previous studies mammalian Fused (Fu) (Stk36), putative serine‐threonine kinase, reveal critical function Fu pair construction orientation that...
During the EU Project PartEmis, microphysical properties of aircraft combustion aerosol were investigated. This study is focused on ability exhaust aerosols to act as cloud condensation nuclei (CCN). The combustor was operated at two different conditions representing old and modern engine technology. CCN concentrations measured with University Vienna counter [ Giebl et al. , 2002 ] supersaturations around 0.7%. activation ratio (fraction in total aerosol) depended fuel sulphur content (FSC)...
Cilia are motile and sensory organelles with critical roles in physiology. Ciliary defects can cause numerous human disease symptoms including polycystic kidneys, hydrocephalus, retinal degeneration. Despite the importance of these organelles, their assembly function is not fully understood. The unicellular green alga Chlamydomonas reinhardtii has many advantages as a model system for studies ciliary function. Here we describe our initial efforts to build chemical-biology toolkit augment...
It is suggested that if the γ-ray dosage received by radium therapists during their work could be assessed (even only roughly), more specific opinion might formed as to what levels of exposure have proved safe. Calculations and measurements local integral dose mould technicians are made in order make such assessment. On basis these results implications various proposed standards protection examined set out terms actual working conditions. For this purpose considered categories which it seems...
A series of measurements by Sievert's condenser chamber technique the dosage, due to 2-gramme radium bomb at Westminster Hospital, within a human cadaver are described and compared with similar water phantom. It is shown that for sites extensively surrounded either or tissue, dosage identical. For regions near boundaries tissues, however, measured different from in an extensive suggested such regions, volume (or other phantom material) should be used, equivalent part body undergoing...
Data have been published recently (7, 11–13, 18, 19) concerning the log survival curves for a number of mammalian cells in vitro and vivo which, vitro, included variety malignant non-malignant cell types human origin (19). From sum total these results, it is probable that mean lethal dose radiation populations well oxygenated environments may prove to be species characteristic only insignificantly affected by type or transformation state (13). When studied are anoxic, curve obtained still...
A method is described whereby the quality of “tissue” radiations in radium therapy may be estimated from ratio ionisations produced ionisation chambers, materials having different atomic numbers. Using method, a study has been made tissue for various conditions approximating to those used therapy. The results and their implications are discussed. show that elektron metal chambers should quite satisfactory measurement depth teletherapy.
An account is given of the construction a compact 2-gramme radium teletherapy unit, which also arranged to allow safe removal special 1-gramme source for contact irradiation. Details are radiation fields available from unit teletherapy.