Detection of Cortical Inflammatory Lesions by Double Inversion Recovery Magnetic Resonance Imaging in Patients With Multiple Sclerosis

• DOI: 10.1001/archneur.64.10.1416
• Publication Date: 2007-10-08T20:33:20Z
• Authors: Massimiliano Cala...; Nicola De Stefano; Matteo Atzori; Valentina Bernardi; Irene Mattisi; Luigi Barachino; Aldo Morra; Luciano Rinaldi; Chiara Romualdi; Paola Perini; Leontino Battistin; Paolo Gallo
• Keywords: Parenchyma; Clinical Significance

Background: A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis (MS) has been demonstrated by ex vivo studies.Objective: To determine frequency, time appearance, and clinical relevance intracortical lesions (ICLs) MS vivo.Design: Double inversion recovery sequence study.Setting: Multiple Sclerosis Centre Veneto Region.Patients: We enrolled 380 (116 clinically isolated syndrome [CIS], 163 relapsingremitting [RRMS], 101 secondary progressive [SPMS]) 40 age-and sex-matched healthy volunteers between May 1, 2005, December 31, 2006.Main Outcome Measures: assessed frequency number ICLs brain parenchyma fraction, white matter T2 lesion volume, disability.Results: Although never observed volunteers, were detected 58% (36%