Interferon Beta–Induced Restoration of Regulatory T-Cell Function in Multiple Sclerosis Is Prompted by an Increase in Newly Generated Naive Regulatory T Cells

• DOI: 10.1001/archneur.65.11.1434
• Publication Date: 2008-11-10T21:19:16Z
• Authors: Mirjam Korporal; Juergen Haas; Bettina Balint; Benedikt Fritzsching; Alexander Schwarz; Sigrid Moeller; Brigitte Fritz; Elisabeth Suri-Payer; Brigitte Wildemann
• Keywords: Homeostasis; BETA (programming language); Interferon beta-1a

Naturally occurring regulatory T (T(reg)) cells are functionally impaired in patients with relapsing-remitting multiple sclerosis. We recently showed that prevalences of newly generated CD31-coexpressing naive T(reg) (recent thymic emigrant-T(reg) cells) critical for suppressive function circulating cells, and a shift the homeostatic composition T(reg)-cell subsets related to reduced de novo generation recent may contribute sclerosis (MS)-related dysfunction. Interferon beta, an immunomodulatory agent established efficacy MS, lowers relapse rates slows disease progression. Emerging evidence suggests capacity increase MS undergoing treatment interferon although mechanisms mediating this effect uncertain.To evaluate beta on activity homeostasis MS.Twenty 18 healthy control subjects.Administration beta.Effect capacity.Suppressive capacities were consistently upregulated at 3 6 months after beta. The restoration was paralleled by increased coincidental reduction memory cells.The inhibitory mediated can be explained its balance within cell compartment.